P
Peter A. Frenkel
Researcher at University of Texas Southwestern Medical Center
Publications - 9
Citations - 1041
Peter A. Frenkel is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Gene delivery & Stent. The author has an hindex of 7, co-authored 9 publications receiving 1020 citations. Previous affiliations of Peter A. Frenkel include Veterans Health Administration.
Papers
More filters
Journal ArticleDOI
Ultrasound-Targeted Microbubble Destruction Can Repeatedly Direct Highly Specific Plasmid Expression to the Heart
TL;DR: Ultrasound-mediated destruction of microbubbles directs plasmid transgene expression to the heart with much greater specificity than viral vectors and can be regulated by repeated treatments, a promising method for cardiac gene therapy.
Journal ArticleDOI
Optimization of ultrasound parameters for cardiac gene delivery of adenoviral or plasmid deoxyribonucleic acid by ultrasound-targeted microbubble destruction.
TL;DR: Optimal ultrasound parameters for this technique include low-transmission frequency, maximal mechanical index, and ECG triggering to allow complete filling of the myocardial capillary bed by microbubbles and holds great promise in applying the rapidly expanding repertoire of gene therapies being developed for cardiac disease.
Journal ArticleDOI
DNA-loaded albumin microbubbles enhance ultrasound-mediated transfection in vitro.
Peter A. Frenkel,Peter A. Frenkel,Shuyuan Chen,T. O. Thai,Ralph V. Shohet,Paul A. Grayburn,Paul A. Grayburn +6 more
TL;DR: DNA loading of microbubbles enhances gene expression and transfection efficiency in US-targeted transfections in vitro and may represent an improved avenue for therapeutic gene delivery in vivo.
Journal ArticleDOI
Targeting of VEGF-mediated angiogenesis to rat myocardium using ultrasonic destruction of microbubbles
Grzegorz Korpanty,Shuyuan Chen,Shuyuan Chen,Ralph V. Shohet,Jiahuan Ding,B Yang,Peter A. Frenkel,Peter A. Frenkel,Paul A. Grayburn,Paul A. Grayburn +9 more
TL;DR: Noninvasive delivery of hVEGF165 to rat myocardium by UTMD resulted in significant increases in myocardial capillary and arteriolar density, and hypercellular foci associated with hVE GF165 expression and endothelial cell markers were shown.
Journal ArticleDOI
Bioresorbable polymeric stents: current status and future promise
Robert C. Eberhart,Shih Horng Su,Kytai T. Nguyen,Meital Zilberman,Liping Tang,Kevin D. Nelson,Peter A. Frenkel +6 more
TL;DR: Following a brief review of metal stent technology, the emerging class of expandable, bioresorbable polymeric stents is described, with emphasis on developments in the authors' laboratory.