R
Ralph V. Shohet
Researcher at University of Hawaii
Publications - 61
Citations - 4443
Ralph V. Shohet is an academic researcher from University of Hawaii. The author has contributed to research in topics: Population & Microbubbles. The author has an hindex of 29, co-authored 55 publications receiving 4210 citations. Previous affiliations of Ralph V. Shohet include University of Hawaii at Manoa & University of Texas Southwestern Medical Center.
Papers
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Journal ArticleDOI
Echocardiographic Destruction of Albumin Microbubbles Directs Gene Delivery to the Myocardium
Ralph V. Shohet,Shuyuan Chen,Yan Ting Zhou,Zhuowei Wang,Robert S. Meidell,Roger H Unger,Paul A. Grayburn,Paul A. Grayburn +7 more
TL;DR: Ulasound-mediated destruction of albumin-coated microbubbles is a promising method for the delivery of bioactive agents to the heart.
Journal ArticleDOI
Ultrasound-Targeted Microbubble Destruction Can Repeatedly Direct Highly Specific Plasmid Expression to the Heart
TL;DR: Ultrasound-mediated destruction of microbubbles directs plasmid transgene expression to the heart with much greater specificity than viral vectors and can be regulated by repeated treatments, a promising method for cardiac gene therapy.
Journal ArticleDOI
Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells
Zhen Yan,James DeGregori,Ralph V. Shohet,Gustavo Leone,Bruce Stillman,Joseph R. Nevins,R. Sanders Williams +6 more
TL;DR: It is concluded that expression of human Cdc6 is regulated in response to mitogenic signals though transcriptional control mechanisms involving E2F proteins, and that CDC6 is required for initiation of DNA replication in mammalian cells.
Journal ArticleDOI
Use of ultrasound contrast agents for gene or drug delivery in cardiovascular medicine.
TL;DR: A critical update of published studies using ultrasound contrast agents for therapeutic use is given and the potential applications and limitations of this technique are discussed and future applications in cardiovascular medicine are suggested.
Journal ArticleDOI
Optimization of ultrasound parameters for cardiac gene delivery of adenoviral or plasmid deoxyribonucleic acid by ultrasound-targeted microbubble destruction.
TL;DR: Optimal ultrasound parameters for this technique include low-transmission frequency, maximal mechanical index, and ECG triggering to allow complete filling of the myocardial capillary bed by microbubbles and holds great promise in applying the rapidly expanding repertoire of gene therapies being developed for cardiac disease.