Showing papers by "Peter Buneman published in 2009"
University of Edinburgh1, National Institutes of Health2, University of Washington3, University of Cambridge4, GlaxoSmithKline5, University of California, Irvine6, University of Michigan7, University of California, Los Angeles8, University of Dundee9, Centre national de la recherche scientifique10, European Bioinformatics Institute11
TL;DR: The IUPHAR database (IUPHar-DB) integrates peer-reviewed pharmacological, chemical, genetic, functional and anatomical information on the 354 nonsensory G protein-coupled receptors, 71 ligand-gated ion channel subunits and 141 voltage- gated-like ionChannel subunits encoded by the human, rat and mouse genomes.
Abstract: The IUPHAR database (IUPHAR-DB) integrates peer-reviewed pharmacological, chemical, genetic, functional and anatomical information on the 354 nonsensory G protein-coupled receptors (GPCRs), 71 ligand-gated ion channel subunits and 141 voltage-gated-like ion channel subunits encoded by the human, rat and mouse genomes. These genes represent the targets of approximately one-third of currently approved drugs and are a major focus of drug discovery and development programs in the pharmaceutical industry. IUPHAR-DB provides a comprehensive description of the genes and their functions, with information on protein structure and interactions, ligands, expression patterns, signaling mechanisms, functional assays and biologically important receptor variants (e.g. single nucleotide polymorphisms and splice variants). In addition, the phenotypes resulting from altered gene expression (e.g. in genetically altered animals or in human genetic disorders) are described. The content of the database is peer reviewed by members of the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR); the data are provided through manual curation of the primary literature by a network of over 60 subcommittees of NC-IUPHAR. Links to other bioinformatics resources, such as NCBI, Uniprot, HGNC and the rat and mouse genome databases are provided. IUPHAR-DB is freely available at http://www.iuphar-db.org.
229 citations
Book•
02 Jun 2009TL;DR: This tutorial will attempt to provide an overview of research in provenance in databases with a focus on recent database research and technology in this area.
Abstract: The provenance of data has recently been recognized as central tothe trust one places in data. It is also important to annotation, todata integration and to probabilistic databases. Three workshops havebeen held on the topic, and it has been the focus of several researchprojects and prototype systems. This tutorial will attempt to providean overview of research in provenance in databases with a focus onrecent database research and technology in this area. This tutorialis aimed at a general database research audience and at people whowork with scientific data.
187 citations
TL;DR: This paper is based on the paper given by the authors at the 5th International Digital Curation Conference, December 2009, and received November 2009, published December 2009.
Abstract: This paper is based on the paper given by the authors at the 5th International Digital Curation Conference, December 2009; received November 2009, published December 2009.
10 citations