P
Peter Chen
Researcher at Cedars-Sinai Medical Center
Publications - 126
Citations - 5455
Peter Chen is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Medicine & Lung injury. The author has an hindex of 30, co-authored 100 publications receiving 3375 citations. Previous affiliations of Peter Chen include University of Washington & University of Texas Southwestern Medical Center.
Papers
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Journal ArticleDOI
SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19.
Peter Chen,Ajay Nirula,Barry Heller,Robert L. Gottlieb,Joseph Boscia,Jason Morris,Gregory D. Huhn,Jose Cardona,Bharat Mocherla,Valentina Stosor,Imad Shawa,Andrew C. Adams,Jacob Van Naarden,Kenneth L. Custer,Lei Shen,Michael Durante,Gerard J. Oakley,Andrew E. Schade,Janelle Sabo,Dipak R. Patel,Paul Klekotka,Daniel Skovronsky +21 more
TL;DR: In this interim analysis of a phase 2 trial, one of three doses of neutralizing antibody LY-CoV555 appeared to accelerate the natural decline in viral load over time, whereas the other doses had not by day 11.
Journal ArticleDOI
Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19: A Randomized Clinical Trial.
Robert L. Gottlieb,Ajay Nirula,Peter Chen,Joseph Boscia,Barry Heller,Jason Morris,Gregory D. Huhn,Jose Cardona,Bharat Mocherla,Valentina Stosor,Imad Shawa,Princy Kumar,Andrew C. Adams,Jacob Van Naarden,Kenneth L. Custer,Michael Durante,Gerard J. Oakley,Andrew E. Schade,Timothy R. Holzer,Philip J. Ebert,Richard E. Higgs,Nicole L. Kallewaard,Janelle Sabo,Dipak R. Patel,Paul Klekotka,Lei Shen,Daniel Skovronsky +26 more
TL;DR: The BLAZE-1 trial as mentioned in this paper evaluated the effect of bamlanivimab monotherapy and combination therapy on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load in mild to moderate COVID-19.
Journal ArticleDOI
Single-Cell Deconvolution of Fibroblast Heterogeneity in Mouse Pulmonary Fibrosis.
Ting Xie,Yizhou Wang,Nan Deng,Guanling Huang,Forough Taghavifar,Yan Geng,Ningshan Liu,Vrishika Kulur,Changfu Yao,Peter Chen,Zhengqiu Liu,Barry R. Stripp,Jie Tang,Jiurong Liang,Paul W. Noble,Dianhua Jiang +15 more
TL;DR: A collection of single-cell transcriptomes and the distinct classification of fibroblast subsets provide a new resource for understanding the fibroblasts landscape and the roles of fibrablasts in fibrotic diseases.
Journal ArticleDOI
Alveolar Epithelial Type II Cells as Drivers of Lung Fibrosis in Idiopathic Pulmonary Fibrosis
TL;DR: The homeostatic role of AT2 cells and the studies that have recently defined the heterogeneity of this population of cells are discussed and the mechanisms of At2 death and dysfunction in the context of lung fibrosis are reviewed.
Journal ArticleDOI
Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis
Changfu Yao,Xiangrong Guan,Gianni Carraro,Tanyalak Parimon,Xue Liu,Guanling Huang,Apoorva Mulay,Harmik J. Soukiasian,Gregory David,S. Samuel Weigt,John A. Belperio,Peter Chen,Dianhua Jiang,Paul W. Noble,Barry R. Stripp +14 more
TL;DR: It is established that senescence rather than loss of AT2 cells promotes progressive fibrosis and show that either genetic or pharmacologic interventions targeting p53 activation orSenescence block fibrogenesis.