C
Changfu Yao
Researcher at Cedars-Sinai Medical Center
Publications - 61
Citations - 1984
Changfu Yao is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Lung & Progenitor cell. The author has an hindex of 17, co-authored 49 publications receiving 990 citations. Previous affiliations of Changfu Yao include Iowa State University & Nankai University.
Papers
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Journal ArticleDOI
Single-Cell Deconvolution of Fibroblast Heterogeneity in Mouse Pulmonary Fibrosis.
Ting Xie,Yizhou Wang,Nan Deng,Guanling Huang,Forough Taghavifar,Yan Geng,Ningshan Liu,Vrishika Kulur,Changfu Yao,Peter Chen,Zhengqiu Liu,Barry R. Stripp,Jie Tang,Jiurong Liang,Paul W. Noble,Dianhua Jiang +15 more
TL;DR: A collection of single-cell transcriptomes and the distinct classification of fibroblast subsets provide a new resource for understanding the fibroblasts landscape and the roles of fibrablasts in fibrotic diseases.
Journal ArticleDOI
Alveolar Epithelial Type II Cells as Drivers of Lung Fibrosis in Idiopathic Pulmonary Fibrosis
TL;DR: The homeostatic role of AT2 cells and the studies that have recently defined the heterogeneity of this population of cells are discussed and the mechanisms of At2 death and dysfunction in the context of lung fibrosis are reviewed.
Journal ArticleDOI
Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis
Changfu Yao,Xiangrong Guan,Gianni Carraro,Tanyalak Parimon,Xue Liu,Guanling Huang,Apoorva Mulay,Harmik J. Soukiasian,Gregory David,S. Samuel Weigt,John A. Belperio,Peter Chen,Dianhua Jiang,Paul W. Noble,Barry R. Stripp +14 more
TL;DR: It is established that senescence rather than loss of AT2 cells promotes progressive fibrosis and show that either genetic or pharmacologic interventions targeting p53 activation orSenescence block fibrogenesis.
Journal ArticleDOI
SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery.
Apoorva Mulay,Bindu Konda,Gustavo Garcia,Changfu Yao,Stephen Beil,Jaquelyn M. Villalba,Jaquelyn M. Villalba,Colin Koziol,Chandani Sen,Arunima Purkayastha,Jay K. Kolls,Derek Pociask,Patrizia Pessina,Patrizia Pessina,Julio Sainz de Aja,Julio Sainz de Aja,Carolina Garcia-de-Alba,Carolina Garcia-de-Alba,Carla F. Kim,Carla F. Kim,Brigitte N. Gomperts,Vaithilingaraja Arumugaswami,Barry R. Stripp +22 more
TL;DR: Wang et al. as discussed by the authors developed primary human lung epithelial infection models to understand initial responses of proximal and distal lung epithelium to SARS-CoV-2 infection.
Journal ArticleDOI
Rare SOX2+ Airway Progenitor Cells Generate KRT5+ Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection.
Samriddha Ray,Norika Chiba,Changfu Yao,Xiangrong Guan,Alicia M. McConnell,Brian Brockway,Loretta G. Que,Jonathan L. McQualter,Barry R. Stripp,Barry R. Stripp +9 more
TL;DR: It is found that the wound-healing response begins with proliferation of SOX2+ SCGB1A1− K RT5− progenitor cells in airways, and it is shown that local alveolar progenitors do not contribute to nascent KRT5+ cells after injury.