P
Peter Grzesik
Researcher at Johns Hopkins University
Publications - 8
Citations - 97
Peter Grzesik is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Gene & Capsid. The author has an hindex of 4, co-authored 7 publications receiving 67 citations. Previous affiliations of Peter Grzesik include Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Genome-wide engineering of an infectious clone of herpes simplex virus type 1 using synthetic genomics assembly methods.
Lauren M. Oldfield,Peter Grzesik,Alexander A. Voorhies,Nina Alperovich,Derek MacMath,Claudia D. Najera,Diya Sabrina Chandra,Sanjana Prasad,Vladimir N. Noskov,Michael G. Montague,Robert Friedman,Prashant Desai,Sanjay Vashee +12 more
TL;DR: An application of synthetic genomics assembly tools that enables rapid and efficient generation of combinatorial mutations in herpesvirus genomes is described, which can help understand basic virus biology, facilitate vaccine development, and aid development of next-generation virus-based delivery systems.
Journal ArticleDOI
Efficient size-independent chromosome delivery from yeast to cultured cell lines.
David M. Brown,Yujia Alina Chan,Prashant Desai,Peter Grzesik,Lauren M. Oldfield,Sanjay Vashee,Jeffrey C. Way,Pamela A. Silver,Pamela A. Silver,John I. Glass +9 more
TL;DR: This work adapted the method to rapidly deliver a 152 kb herpes simplex virus 1 genome cloned in yeast into mammalian cells to produce infectious virus and optimized the delivery process for multiple mammalian, avian, and insect cell lines.
Journal ArticleDOI
Visualization of herpes simplex virus type 1 virions using fluorescent colors.
TL;DR: The repertoire of colors available as fusion to the small capsid protein, VP26, so that they can be used alone or in conjunction with other fluorescent tags to follow the virus as it enters and replicates within the cell is increased.
Journal ArticleDOI
Functional Domains of the Herpes Simplex Virus Type 1 Tegument Protein pUL37: The Amino Terminus is Dispensable for Virus Replication in Tissue Culture
Peter Grzesik,Erin N. Pryce,Akshay Bhalala,Mannika Vij,Ray Ahmed,Lyns Etienne,Patric J. Perez,J. Michael McCaffery,Prashant Desai +8 more
TL;DR: The mutations identified in this study are recognized as significant candidates for further analysis of the pUL37 function and may unveil previously undiscovered roles and interactions of this essential tegument gene.
Journal ArticleDOI
Incorporation of the Kaposi's sarcoma-associated herpesvirus capsid vertex-specific component (CVSC) into self-assembled capsids.
TL;DR: Biochemically how the KSHV CVSC interacts with the capsid shell is revealed, which is important for capsid maturation in herpesvirus-infected cells.