P
Peter J. Hornsby
Researcher at Baylor College of Medicine
Publications - 107
Citations - 5424
Peter J. Hornsby is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Adrenal cortex & Cell culture. The author has an hindex of 38, co-authored 107 publications receiving 5334 citations. Previous affiliations of Peter J. Hornsby include University of California, San Diego & City of Hope National Medical Center.
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Pathophysiologically relevant concentrations of tumor necrosis factor- α promote progressive left ventricular dysfunction and remodeling in rats
Biykem Bozkurt,Scott B. Kribbs,Fred J. Clubb,Lloyd H. Michael,Vladimir V. Didenko,Peter J. Hornsby,Yukihiro Seta,Hakan Oral,Francis G. Spinale,Douglas L. Mann +9 more
TL;DR: These studies suggest that pathophysiologically relevant concentrations of TNF-alpha are sufficient to mimic certain aspects of the phenotype observed in experimental and clinical models of heart failure.
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The zona reticularis is the site of biosynthesis of dehydroepiandrosterone and dehydroepiandrosterone sulfate in the adult human adrenal cortex resulting from its low expression of 3 beta-hydroxysteroid dehydrogenase
TL;DR: The most likely cause of the age-related decline in adrenal androgen biosynthesis is an age- related decline in the number of functional reticularis cells, without a major change in the differentiated properties of the zonal cells as a function of age.
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Presence of double-strand breaks with single-base 3' overhangs in cells undergoing apoptosis but not necrosis.
TL;DR: The specificity of the in situ ligation of 3'-overhang fragments to apoptotic nuclei indicates that apoptotic cells labeled in this way can readily be distinguished from cells with nonapoptotic DNA damage.
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The role of lipid peroxidation and biological antioxidants in the function of the adrenal cortex. Part 2
TL;DR: It will be suggested that, while lipid peroxidation is a process against which the adrenocortical cell must protect itself, it may also play a unique role in determining the differentiated properties of the adrenal cortex.
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Postmenopausal dehydroepiandrosterone administration increases free insulin-like growth factor-I and decreases high-density lipoprotein: a six-month trial
Peter R. Casson,Nanette Santoro,Karen E. Elkind-Hirsch,Sandra Ann Carson,Peter J. Hornsby,Guy E. Abraham,John E. Buster +6 more
TL;DR: In this article, the effect of 6 months of oral postmenopausal DHEA therapy on serum DHEAs and T levels and on physiologic endpoints including lipoproteins and insulin-like growth factor-I (IGF-I) was evaluated.