P
Peter J. L. M. Quaedflieg
Researcher at DSM
Publications - 94
Citations - 1804
Peter J. L. M. Quaedflieg is an academic researcher from DSM. The author has contributed to research in topics: Amino acid & Peptide. The author has an hindex of 20, co-authored 94 publications receiving 1660 citations. Previous affiliations of Peter J. L. M. Quaedflieg include Radboud University Nijmegen.
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Journal ArticleDOI
Organocatalysed asymmetric Mannich reactions.
TL;DR: This tutorial review provides an overview of the recent history of the asymmetric organocatalysed Mannich reaction, including scope and limitations, and application of different catalyst systems.
Journal ArticleDOI
Mild and efficient deprotection of the amine protecting p-methoxyphenyl (PMP) group
Jorge M. M. Verkade,Lieke J. C. van Hemert,Peter J. L. M. Quaedflieg,Paul L. Alsters,Floris L. van Delft,Floris P. J. T. Rutjes +5 more
TL;DR: In this paper, mild and efficient procedures for deprotection of the amine nitrogen protecting p-methoxyphenyl (PMP) group are described, using trichloroisocyanuric acid (TCCA) and periodic acid.
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Versatile Peptide C-Terminal Functionalization via a Computationally Engineered Peptide Amidase
Bian Wu,Hein J. Wijma,Lu Song,Henriëtte J. Rozeboom,Claudia Poloni,Yu’e Tian,Muhammad I. Arif,Timo Nuijens,Peter J. L. M. Quaedflieg,Wiktor Szymanski,Ben L. Feringa,Dick B. Janssen +11 more
TL;DR: This work explored the peptide amidase from Stenotrophomonas maltophilia as a versatile catalyst for diverse carboxy-terminal peptide modification reactions and discovered a number of stabilizing mutations contributing to the enhanced robustness.
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Click chemistry as a means to functionalize macroporous PolyHIPE
David Cummins,Christopher J. Duxbury,Peter J. L. M. Quaedflieg,Pieter C. M. M. Magusin,CE Cor Koning,Andreas Heise,Andreas Heise +6 more
TL;DR: In this article, the surface functionalization of macroporous polyHIPE was achieved by Huisgen-type "click" chemistry, where a 600-800 nm thick layer of poly(glycidyl methacrylate) (pGMA) was grafted from the pHIPE surface by atom transfer radical polymerization.
Journal ArticleDOI
Omniligase-1: A Powerful Tool for Peptide Head-to-Tail Cyclization
Marcel Schmidt,Ana Toplak,Peter J. L. M. Quaedflieg,Hans Ippel,Gaston J. J. Richelle,Tilman M. Hackeng,Jan H. van Maarseveen,Timo Nuijens +7 more
TL;DR: In this paper, the use of the peptide ligase termed omniligase-1 as a versatile and broadly applicable enzymatic tool for peptide cyclization was demonstrated.