P
Peter L. Weissberg
Researcher at University of Cambridge
Publications - 79
Citations - 10507
Peter L. Weissberg is an academic researcher from University of Cambridge. The author has contributed to research in topics: Vascular smooth muscle & Apoptosis. The author has an hindex of 49, co-authored 79 publications receiving 10052 citations. Previous affiliations of Peter L. Weissberg include University of Washington & Leicester Royal Infirmary.
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Journal ArticleDOI
Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD.
Joanne L. Reynolds,Alexis J. Joannides,Jeremy N. Skepper,Rosamund McNair,Leon J. Schurgers,Diane Proudfoot,Willi Jahnen-Dechent,Peter L. Weissberg,Catherine M. Shanahan +8 more
TL;DR: In the context of raised Ca and P, vascular calcification is a modifiable, cell-mediated process regulated by vesicle release, and perturbation of the production or function of these inhibitors would lead to accelerated vascular calcifying.
Journal ArticleDOI
Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis.
Martin R. Bennett,Kirsty Macdonald,Shiu-Wan Chan,J. Paul Luzio,Robert D. Simari,Peter L. Weissberg +5 more
TL;DR: In human vascular smooth muscle cells, p53 activation transiently increased surface Fas (CD95) expression by transport from the Golgi complex and p53 can mediate apoptosis through Fas transport from cytoplasmic stores.
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Apoptosis regulates human vascular calcification in vitro: evidence for initiation of vascular calcification by apoptotic bodies.
Diane Proudfoot,Jeremy N. Skepper,Laszlo Hegyi,Martin R. Bennett,Catherine M. Shanahan,Peter L. Weissberg +5 more
TL;DR: It is reported that apoptosis occurs in a human vascular calcification model in which postconfluent vascular smooth muscle cell (VSMC) cultures form nodules spontaneously and calcify after ≈28 days, and incubation of VSMC-derived apoptotic bodies with 45Ca demonstrated that they can concentrate calcium.
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Medial Localization of Mineralization-Regulating Proteins in Association With Mönckeberg’s Sclerosis Evidence for Smooth Muscle Cell–Mediated Vascular Calcification
Catherine M. Shanahan,Nathaniel R.B. Cary,Jon R. Salisbury,Diane Proudfoot,Peter L. Weissberg,Michael Edmonds +5 more
TL;DR: Examination of gene expression in vessels with Mönckeberg's sclerosis indicates that medial calcification in MS lesions is an active process potentially orchestrated by phenotypically modified VSMCs.
Journal ArticleDOI
Nesprin-1 and -2 are involved in the pathogenesis of Emery–Dreifuss muscular dystrophy and are critical for nuclear envelope integrity
Qiuping Zhang,Cornelia Bethmann,Nathalie F. Worth,John D. Davies,Christina Wasner,Anja Feuer,Cassandra D. Ragnauth,Qijian Yi,Jason A. Mellad,Derek T. Warren,Matthew A. Wheeler,Juliet A. Ellis,Jeremy N. Skepper,Matthias Vorgerd,Beate Schlotter-Weigel,Peter L. Weissberg,Roland G. Roberts,Manfred Wehnert,Catherine M. Shanahan +18 more
TL;DR: Data suggest that EDMD may be caused, in part, by uncoupling of the nucleoskeleton and cytoskeleton because of perturbed nesprin/emerin/lamin interactions.