C
Catherine M. Shanahan
Researcher at King's College London
Publications - 223
Citations - 23448
Catherine M. Shanahan is an academic researcher from King's College London. The author has contributed to research in topics: Vascular smooth muscle & Calcification. The author has an hindex of 71, co-authored 211 publications receiving 20467 citations. Previous affiliations of Catherine M. Shanahan include Leicester Royal Infirmary & University of Cambridge.
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Journal ArticleDOI
Coupling of the nucleus and cytoplasm: Role of the LINC complex
Melissa Crisp,Qian Liu,Kyle J. Roux,Jerome B. Rattner,Catherine M. Shanahan,Brian Burke,Phillip D. Stahl,Didier Hodzic +7 more
TL;DR: Data from this study support a model in which Sun proteins tether nesprins in the ONM via interactions spanning the PNS, and form a complex that links the nucleoskeleton and cytoskeleton (the LINC complex).
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Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD.
Joanne L. Reynolds,Alexis J. Joannides,Jeremy N. Skepper,Rosamund McNair,Leon J. Schurgers,Diane Proudfoot,Willi Jahnen-Dechent,Peter L. Weissberg,Catherine M. Shanahan +8 more
TL;DR: In the context of raised Ca and P, vascular calcification is a modifiable, cell-mediated process regulated by vesicle release, and perturbation of the production or function of these inhibitors would lead to accelerated vascular calcifying.
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Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores
Alberto Elosegui-Artola,Ion Andreu,Ion Andreu,Amy E. M. Beedle,Amy E. M. Beedle,Ainhoa Lezamiz,Ainhoa Lezamiz,Marina Uroz,Anita Joanna Kosmalska,Roger Oria,Jenny Z. Kechagia,Palma Rico-Lastres,Palma Rico-Lastres,Anabel-Lise Le Roux,Catherine M. Shanahan,Xavier Trepat,Daniel Navajas,Sergi Garcia-Manyes,Sergi Garcia-Manyes,Pere Roca-Cusachs +19 more
TL;DR: This work shows that force applied to the nucleus directly drives YAP nuclear translocation by decreasing the mechanical restriction of nuclear pores to molecular transport, demonstrated for YAP but with potential general applicability in transcriptional regulation.
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Arterial Calcification in Chronic Kidney Disease: Key Roles for Calcium and Phosphate
TL;DR: A major role is suggested for elevated P in promoting osteogenic/chondrogenic differentiation of VSMC, whereas elevated Ca has a predominant role in promoting VSMC apoptosis and vesicle release.
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Apoptosis regulates human vascular calcification in vitro: evidence for initiation of vascular calcification by apoptotic bodies.
Diane Proudfoot,Jeremy N. Skepper,Laszlo Hegyi,Martin R. Bennett,Catherine M. Shanahan,Peter L. Weissberg +5 more
TL;DR: It is reported that apoptosis occurs in a human vascular calcification model in which postconfluent vascular smooth muscle cell (VSMC) cultures form nodules spontaneously and calcify after ≈28 days, and incubation of VSMC-derived apoptotic bodies with 45Ca demonstrated that they can concentrate calcium.