S
Shiu-Wan Chan
Researcher at University of Manchester
Publications - 35
Citations - 5447
Shiu-Wan Chan is an academic researcher from University of Manchester. The author has contributed to research in topics: Hepatitis C virus & Apoptosis. The author has an hindex of 17, co-authored 35 publications receiving 5356 citations. Previous affiliations of Shiu-Wan Chan include University of Edinburgh & University of Cambridge.
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Journal ArticleDOI
Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region
Peter Simmonds,Edward C. Holmes,Tai-An Cha,Shiu-Wan Chan,F. McOmish,Irvine Bruce,Beall Eileen,P L Yap,Janice A. Kolberg,Mickey S. Urdea +9 more
TL;DR: A new nomenclature for HCV variants is proposed in this communication that reflects the two-tiered nature of sequence differences between different viral isolates and describes criteria that would enable new variants to be assigned within the classification as they are discovered.
Journal ArticleDOI
A proposed system for the nomenclature of hepatitis C viral genotypes
Peter Simmonds,A. Alberti,Harvey J. Alter,Ferruccio Bonino,Daniel W. Bradley,Christian Bréchot,Johannes T. Brouwer,Shiu-Wan Chan,Kazuaki Chayama,Ding-Shinn Chen +9 more
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Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis.
Martin R. Bennett,Kirsty Macdonald,Shiu-Wan Chan,J. Paul Luzio,Robert D. Simari,Peter L. Weissberg +5 more
TL;DR: In human vascular smooth muscle cells, p53 activation transiently increased surface Fas (CD95) expression by transport from the Golgi complex and p53 can mediate apoptosis through Fas transport from cytoplasmic stores.
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Sequence variability in the 5' non-coding region of hepatitis C virus: identification of a new virus type and restrictions on sequence diversity.
Peter Simmonds,F. McOmish,P L Yap,Shiu-Wan Chan,C. K. Lin,G. Dusheiko,A A Saeed,Edward C. Holmes +7 more
TL;DR: The specific nucleotide substitutions in the 5' NCR that differentiate each of the four HCV types can be detected by restriction enzyme cleavage, providing a rapid and reliable method for virus typing.
Journal ArticleDOI
Analysis of a new hepatitis C virus type and its phylogenetic relationship to existing variants.
Shiu-Wan Chan,F. McOmish,Edward C. Holmes,B. C. Dow,John F. Peutherer,E.A.C. Follett,P L Yap,Peter Simmonds +7 more
TL;DR: Phylogenetic analysis revealed the existence of three distinct groups of sequences that corresponded to the recently described HCV types 1 and 2 variants, while viral sequences detected in around a third of the blood donors formed a separate phylogenetic group that probably represents infection with a novel virus species.