P
Peter M. Klein
Researcher at Stanford University
Publications - 28
Citations - 1097
Peter M. Klein is an academic researcher from Stanford University. The author has contributed to research in topics: Epilepsy & Epileptogenesis. The author has an hindex of 15, co-authored 27 publications receiving 879 citations. Previous affiliations of Peter M. Klein include Bates College & Boston Children's Hospital.
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Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex
June Goto,Delia M. Talos,Peter M. Klein,Wei Qin,Yvonne Chekaluk,Stefanie Anderl,Izabela A. Malinowska,Alessia Di Nardo,Roderick T. Bronson,Jennifer A. Chan,Harry V. Vinters,Steven G. Kernie,Frances E. Jensen,Mustafa Sahin,David J. Kwiatkowski +14 more
TL;DR: This TSC brain model provides insights into the pathogenesis and organelle dysfunction of giant cells, as well as epilepsy control in patients with T SC, despite prenatal onset of Tsc1 loss and mTOR complex 1 activation in the developing brain.
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The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of rapamycin (mTOR) pathway.
Delia M. Talos,Hongyu Sun,Xiangping Zhou,Erin C. Fitzgerald,Michele Jackson,Peter M. Klein,Victor J. Lan,Annelise Joseph,Frances E. Jensen,Frances E. Jensen +9 more
TL;DR: Findings suggest that in the developing brain the mTORC1 signaling pathway is involved in epileptogenesis and altered social behavior, and that it may be a target for development of novel therapies that eliminate the progressive effects of neonatal seizures.
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Development of later life spontaneous seizures in a rodent model of hypoxia-induced neonatal seizures.
Sanjay N. Rakhade,Peter M. Klein,Thanthao Huynh,Cristina Hilario-Gomez,Bela Kosaras,Alexander Rotenberg,Frances E. Jensen,Frances E. Jensen +7 more
TL;DR: To study the development of epilepsy following hypoxia‐induced neonatal seizures in Long‐Evans rats and to establish the presence of spontaneous seizures in this model of early life seizures, a large number of seizures are reported.
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New Concerns for Neurocognitive Function during Deep Space Exposures to Chronic, Low Dose-Rate, Neutron Radiation.
Munjal M. Acharya,Janet E. Baulch,Peter M. Klein,Al Anoud D. Baddour,Lauren A. Apodaca,Enikö A. Kramár,Leila Alikhani,Camillo Garcia,Maria C. Angulo,Raja S Batra,Christine M Fallgren,Thomas B. Borak,Craig E.L. Stark,Marcello A Wood,Richard A. Britten,Ivan Soltesz,Charles L. Limoli +16 more
TL;DR: It is uncovered that realistic, low dose-rate exposures produce serious neurocognitive complications associated with impaired neurotransmission, and for the first time, some unexpected potential problems associated with deep space travel on all levels of neurological function are revealed.
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Glutamate Receptor 1 Phosphorylation at Serine 831 and 845 Modulates Seizure Susceptibility and Hippocampal Hyperexcitability after Early Life Seizures
Sanjay N. Rakhade,Erin F. Fitzgerald,Peter M. Klein,Chengwen Zhou,Hongyu Sun,Richard L. Huganir,Frances E. Jensen +6 more
TL;DR: Human hippocampal samples from neonatal seizure autopsy cases also showed an increase in GluR1 S831 and S845, supporting the validation of this potential therapeutic target in human tissue.