Ivan Soltesz

TL;DR: Recent findings have started to unravel the operation of central GABA synapses where inhibitory events appear to result from the synchronous opening of only tens of GABAA receptors activated by a saturating concentration of GABA.

TL;DR: It is demonstrated that spontaneous temporal lobe seizures can be detected and terminated by modulating specific cell populations in a spatially restricted manner and a clinical approach built on these principles may overcome many of the side-effects of currently available treatment options.

TL;DR: A mechanistic resolution to the paradox of persistent lowering of seizure threshold despite an upregulation of inhibition is provided by showing that, in the hippocampus of rats that had febrile seizures, the long-lasting enhancement of the widely expressed intrinsic membrane conductance converts the potentiated synaptic inhibition to hyperexcitability in a frequency-dependent manner.

TL;DR: It was concluded that the EEG theta-waves, and the fast EEG rhythm, recorded during ketamine-xylazine anesthesia, share the basic properties of those theta and fast rhythms that are recorded under the effects of other types of anesthetics.

TL;DR: Observations suggest that dendritic currents underlying theta in the awake rat may not be revealed under urethane anesthesia, and cellular‐synaptic generation of rhythmic slow activity in the hippocampus is investigated by intracellular recording from principal cells and basket cells in anesthetized rats.