P
Peter M. van Koetsveld
Researcher at Erasmus University Rotterdam
Publications - 76
Citations - 3234
Peter M. van Koetsveld is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Somatostatin & Somatostatin receptor. The author has an hindex of 29, co-authored 64 publications receiving 2916 citations. Previous affiliations of Peter M. van Koetsveld include Erasmus University Medical Center.
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Journal ArticleDOI
The multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5
Leo J. Hofland,Joost van der Hoek,Richard A Feelders,Maarten O. van Aken,Peter M. van Koetsveld,Marlijn Waaijers,Diana Sprij-Mooij,Christian Bruns,Gisbert Weckbecker,Wouter W. de Herder,Albert Beckers,Steven W. J. Lamberts +11 more
TL;DR: The preferential inhibition of ACTH release by human corticotroph adenoma cells by SOM230 in vitro, suggest that SOM230 may have potential in the treatment of patients with pituitary-dependent Cushing's disease.
Journal ArticleDOI
The Novel Somatostatin Analog SOM230 Is a Potent Inhibitor of Hormone Release by Growth Hormone- and Prolactin-Secreting Pituitary Adenomas in Vitro
Leo J. Hofland,Joost van der Hoek,Peter M. van Koetsveld,Wouter W. de Herder,Marlijn Waaijers,Diana Sprij-Mooij,Christian Bruns,Gisbert Weckbecker,Richard A Feelders,Aart-Jan van der Lely,Albert Beckers,Steven W. J. Lamberts +11 more
TL;DR: The higher number of responders of GH-secreting pituitary adenoma cultures to SOM230, compared with OCT, suggest that SOM230 has the potency to increase the number of acromegalic patients which can be biochemically controlled.
Journal ArticleDOI
Expression of somatostatin, cortistatin, and somatostatin receptors in human monocytes, macrophages, and dendritic cells
Virgil A. S. H. Dalm,P. Martin van Hagen,Peter M. van Koetsveld,Samuel Achilefu,Adriaan B. Houtsmuller,David H. J. Pols,Aart-Jan van der Lely,Steven W. J. Lamberts,Leo J. Hofland +8 more
TL;DR: This study demonstrates for the first time a selective and inducible expression of the recently discovered CST, as well as sst2, in human monocyte-derived cells, suggesting a role for a CST-sst2 system rather than a SS-sSt2 system in these immune cell types.
Journal ArticleDOI
Ghrelin secretion is inhibited by either somatostatin or cortistatin in humans.
Fabio Broglio,Peter M. van Koetsveld,Andrea Benso,C. Gottero,Flavia Prodam,Mauro Papotti,Giampiero Muccioli,C. Gauna,Leo J. Hofland,Romano Deghenghi,Emanuela Arvat,Aart Jan van der Lely,Ezio Ghigo +12 more
TL;DR: It is shown that SRIF and CST strongly inhibits ghrelin secretion that, differently from GH and insulin secretion, persists inhibited even after stopping the infusion of SRIF or CST.
Journal ArticleDOI
Ghrelin drives GH secretion during fasting in man
Alex F. Muller,Steven W. J. Lamberts,Joop A. M. J. L. Janssen,Leo J. Hofland,Peter M. van Koetsveld,Martin Bidlingmaier,Christian J. Strasburger,Ezio Ghigo,Aart Jan van der Lely +8 more
TL;DR: Data indicate that ghrelin is the main driving force behind the enhanced GH secretion during fasting, which could not be explained by changes in insulin, glucose, or free fatty acid levels.