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Leo J. Hofland

Researcher at Erasmus University Rotterdam

Publications -  291
Citations -  14048

Leo J. Hofland is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Somatostatin & Somatostatin receptor. The author has an hindex of 64, co-authored 274 publications receiving 12812 citations.

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The pathophysiological consequences of somatostatin receptor internalization and resistance

TL;DR: The pathophysiological role of somatostatin receptor subtypes in determining the efficacy of treatment of patients with somatstatin receptor-positive tumors using som atostatin analogs is covered, as well as the preclinical and clinical consequences of agonist-induced receptor internalization for somatOSTatin receptors-targeted radio- and chemotherapy.
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[111In-DTPA-D-Phe1]-octreotide, a potential radiopharmaceutical for imaging of somatostatin receptor-positive tumors: synthesis, radiolabeling and in vitro validation

TL;DR: In this article, a single-step labeling procedure was used to detect somatostatin receptor-positive human tumors using radioiodinated analogues of sostatin, both in vitro and in vivo.
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Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes

TL;DR: Gl glucose output by primary hepatocytes is time- and dose-dependently stimulated by AG and inhibited by UAG, and UAG counteracts the stimulatory effect of AG on glucose release.