L
Leo J. Hofland
Researcher at Erasmus University Rotterdam
Publications - 291
Citations - 14048
Leo J. Hofland is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Somatostatin & Somatostatin receptor. The author has an hindex of 64, co-authored 274 publications receiving 12812 citations.
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Journal ArticleDOI
Treatment of Adrenocorticotropin-Dependent Cushing’s Syndrome: A Consensus Statement
Beverly M. K. Biller,Ashley B. Grossman,Paul M. Stewart,Shlomo Melmed,Xavier Bertagna,Jérôme Bertherat,Michael Buchfelder,Annamaria Colao,Ad R. M. M. Hermus,Leo J. Hofland,Anne Klibanski,André Lacroix,John R. Lindsay,John Newell-Price,Lynnette K. Nieman,S. Petersenn,Nicoletta Sonino,Günter K. Stalla,Brooke Swearingen,Mary Lee Vance,John A.H. Wass,Marco Boscaro +21 more
TL;DR: Thirty-two leading endocrinologists, clinicians, and neurosurgeons with specific expertise in the management of ACTH-dependent Cushing's syndrome representing nine countries were chosen to address criteria for cure and remission of this disorder.
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The pathophysiological consequences of somatostatin receptor internalization and resistance
TL;DR: The pathophysiological role of somatostatin receptor subtypes in determining the efficacy of treatment of patients with somatstatin receptor-positive tumors using som atostatin analogs is covered, as well as the preclinical and clinical consequences of agonist-induced receptor internalization for somatOSTatin receptors-targeted radio- and chemotherapy.
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[111In-DTPA-D-Phe1]-octreotide, a potential radiopharmaceutical for imaging of somatostatin receptor-positive tumors: synthesis, radiolabeling and in vitro validation
Willem H. Bakker,R. Albert,C. Bruns,Wouter A.P. Breeman,Leo J. Hofland,P. Marbach,J. Pless,D. Pralet,B. Stolz,Jan W. Koper,S. W. J. Lamberts,Theo J. Visser,E.P. Krenning +12 more
TL;DR: In this article, a single-step labeling procedure was used to detect somatostatin receptor-positive human tumors using radioiodinated analogues of sostatin, both in vitro and in vivo.
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Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes
C. Gauna,Patric J.D. Delhanty,Leo J. Hofland,Joop A. M. J. L. Janssen,Fabio Broglio,Fabio Broglio,Richard J. Ross,Ezio Ghigo,Aart Jan van der Lely +8 more
TL;DR: Gl glucose output by primary hepatocytes is time- and dose-dependently stimulated by AG and inhibited by UAG, and UAG counteracts the stimulatory effect of AG on glucose release.
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The Medical Treatment of Cushing’s Disease: Effectiveness of Chronic Treatment with the Dopamine Agonist Cabergoline in Patients Unsuccessfully Treated by Surgery
Rosario Pivonello,Maria Cristina De Martino,Paolo Cappabianca,Monica De Leo,Antongiulio Faggiano,Gaetano Lombardi,Leo J. Hofland,Steven W. J. Lamberts,Annamaria Colao +8 more
TL;DR: It is demonstrated that cabergoline treatment is effective in controlling cortisol secretion for at least 1-2 yr in more than one third of a limited population of patients with CD.