P
Peter R. Chai
Researcher at Brigham and Women's Hospital
Publications - 131
Citations - 3242
Peter R. Chai is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Medicine & Population. The author has an hindex of 21, co-authored 98 publications receiving 1870 citations. Previous affiliations of Peter R. Chai include Brown University & Rhode Island Hospital.
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Journal ArticleDOI
SARS-CoV-2 Titers in Wastewater Are Higher than Expected from Clinically Confirmed Cases
Fuqing Wu,Jianbo Zhang,Amy Xiao,Xiaoqiong Gu,Wei Lin Lee,Federica Armas,Kathryn M. Kauffman,William P. Hanage,Mariana Matus,Newsha Ghaeli,Noriko Endo,Claire Duvallet,Mathilde Poyet,Katya Moniz,Alex D. Washburne,Timothy B. Erickson,Timothy B. Erickson,Peter R. Chai,Peter R. Chai,Janelle R. Thompson,Eric J. Alm +20 more
TL;DR: A laboratory protocol to quantify viral titers in raw sewage via qPCR analysis and validate results with sequencing analysis suggests that the number of positive cases estimated from wastewater viral titer is orders of magnitude greater than the numberof confirmed clinical cases and therefore may significantly impact efforts to understand the case fatality rate and progression of disease.
Posted ContentDOI
SARS-CoV-2 titers in wastewater are higher than expected from clinically confirmed cases
Fuqing Wu,Amy Xiao,Jianbo Zhang,Xiaoqiong Gu,Wei Lin Lee,Kathryn M. Kauffman,William P. Hanage,Mariana Matus,Newsha Ghaeli,Noriko Endo,Claire Duvallet,Katya Moniz,Timothy B. Erickson,Peter R. Chai,Janelle R. Thompson,Eric J. Alm +15 more
TL;DR: Wastewater surveillance at a major urban treatment facility in Massachusetts found the presence of SARS-CoV-2 at high titers in the period from March 18 - 25 using RT-qPCR, and the identity of the PCR product was confirmed by direct DNA sequencing.
Journal ArticleDOI
Dynamics of the self-assembly of complex cellular aggregates on micromolded nonadhesive hydrogels.
TL;DR: It is shown that cells can self-assemble to form a complex toroid shape, and several phenomena indicating that cellular contraction and tension play a significant role in the assembly process of complex shapes are observed.
Posted ContentDOI
SARS-CoV-2 titers in wastewater foreshadow dynamics and clinical presentation of new COVID-19 cases
Fuqing Wu,Amy Xiao,Jianbo Zhang,Katya Moniz,Noriko Endo,Federica Armas,Richard Bonneau,Megan A. Brown,Mary Bushman,Peter R. Chai,Peter R. Chai,Claire Duvallet,Timothy B. Erickson,Timothy B. Erickson,Katelyn Foppe,Newsha Ghaeli,Xiaoqiong Gu,William P. Hanage,Katherine H. Huang,Wei Lin Lee,Mariana Matus,Kyle A. McElroy,Jonathan Nagler,Steven F Rhode,Mauricio Santillana,Mauricio Santillana,Joshua A. Tucker,Stefan Wuertz,Shijie Zhao,Janelle R. Thompson,Eric J. Alm +30 more
TL;DR: In this article, the authors used longitudinal wastewater analysis to track SARS-CoV-2 dynamics in wastewater at a major urban wastewater treatment facility in Massachusetts, between early January and May 2020.
Journal ArticleDOI
SARS-CoV-2 RNA concentrations in wastewater foreshadow dynamics and clinical presentation of new COVID-19 cases.
Fuqing Wu,Amy Xiao,Jianbo Zhang,Katya Moniz,Noriko Endo,Federica Armas,Richard Bonneau,Megan A. Brown,Mary Bushman,Peter R. Chai,Peter R. Chai,Claire Duvallet,Timothy B. Erickson,Timothy B. Erickson,Katelyn Foppe,Newsha Ghaeli,Xiaoqiong Gu,William P. Hanage,Katherine H. Huang,Wei Lin Lee,Mariana Matus,Kyle A. McElroy,Jonathan Nagler,Steven F Rhode,Mauricio Santillana,Mauricio Santillana,Joshua A. Tucker,Stefan Wuertz,Shijie Zhao,Janelle R. Thompson,Eric J. Alm +30 more
TL;DR: In this article, the authors quantify the SARS-CoV-2 concentration and track its dynamics in wastewater at a major urban wastewater treatment facility in Massachusetts, between early January and May 2020.