Peter S. Zammit

TL;DR: Within a normally stable tissue, the satellite cell exhibits archetypal stem cell properties and is competent to form the basal origin of adult muscle regeneration.

TL;DR: Two novel markers of quiescent satellite cells are described: CD34, an established marker of hematopoietic stem cells, and Myf5, the earliest marker of myogenic commitment, which are concluded to define quyingcent, committed precursors and speculate that the CD34−ve, Myf 5−ve minority may be involved in maintaining the lineage-committed majority.

TL;DR: C cultured myofibers are used to model muscle regeneration and it is shown that satellite cells adopt divergent fates, suggesting that satellites either differentiate or switch from terminal myogenesis to maintain the satellite cell pool.

TL;DR: It is confirmed that skeletal muscle does not regenerate without satellite cells, confirming their pivotal and non-redundant role.

TL;DR: Evidence is discussed that puts this enigmatic cell firmly back at the center of adult myogenesis, as bone marrow-derived cells and various intramuscular populations were shown to be able to contribute myonuclei and occupy the satellite cell niche.