P
Peter Spies
Researcher at University of Applied Sciences and Arts Northwestern Switzerland FHNW
Publications - 8
Citations - 363
Peter Spies is an academic researcher from University of Applied Sciences and Arts Northwestern Switzerland FHNW. The author has contributed to research in topics: Membrane protein & Phage display. The author has an hindex of 4, co-authored 7 publications receiving 242 citations.
Papers
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Journal ArticleDOI
Synthetic single domain antibodies for the conformational trapping of membrane proteins
Iwan Zimmermann,Pascal Egloff,Cedric A. J. Hutter,Fabian M. Arnold,Peter Stohler,Nicolas Bocquet,Melanie N. Hug,Sylwia Huber,Martin Siegrist,Lisa Hetemann,Jeniffer Gera,Samira Gmuer,Peter Spies,Daniel Gygax,Eric R. Geertsma,Roger J. P. Dawson,Markus A. Seeger +16 more
TL;DR: An in vitro selection platform based on synthetic single domain antibodies named sybodies, designed to target the limited hydrophilic surfaces of membrane proteins, and designed three sybody libraries that exhibit different shapes and moderate hydrophobicity of the randomized surface.
Journal ArticleDOI
The Sphingolipid Receptor S1PR2 Is a Receptor for Nogo-A Repressing Synaptic Plasticity
Anissa Kempf,Bjoern Tews,Michael E. Arzt,Oliver Weinmann,Franz J. Obermair,Vincent Pernet,Marta Zagrebelsky,Andrea Delekate,Cristina Iobbi,Ajmal Zemmar,Zorica Ristic,Miriam Gullo,Peter Spies,Dana A. Dodd,Daniel Gygax,Martin Korte,Martin E. Schwab +16 more
TL;DR: This study identifies a GPCR, S1PR2, as a receptor for the Nogo-A-Δ20 domain of the membrane protein Nogo A, which inhibits neuronal growth and synaptic plasticity.
Peer ReviewDOI
Author response: Synthetic single domain antibodies for the conformational trapping of membrane proteins
Iwan Zimmermann,Pascal Egloff,Cedric A. J. Hutter,Fabian M. Arnold,Peter Stohler,Nicolas Bocquet,Melanie N. Hug,Sylwia Huber,Martin Siegrist,Lisa Hetemann,Jennifer Gera,Samira Gmür,Peter Spies,Daniel Gygax,Eric R. Geertsma,Roger J. P. Dawson,Markus A. Seeger +16 more
Journal ArticleDOI
Establishment of a miniaturized enzyme-linked immunosorbent assay for human transferrin quantification using an intelligent multifunctional analytical plate.
TL;DR: The results demonstrate that the IMAPlate 5RC96 is a convenient, robust, high-throughput lab device feasible for miniaturized ELISA in an ordinary laboratory.
Patent
Composition for treatment of pathogens that are resistant to tetracyclines
Peter Schneider,Rainer Riedl,Marcel Tigges,Marc Gitzinger,Michel Pieren,Assaf Levi,Mark Sephton,Birgit Schellhorn,Patrik Zueger,Michael Brand,Daniel Gygax,Peter Spies +11 more
TL;DR: In this article, the authors describe compounds and pharmaceutical compositions useful in combination with tetracyclines in the treatment of bacterial infections caused by Gram-positive and Gram-negative pathogens.