S
Sylwia Huber
Researcher at Hoffmann-La Roche
Publications - 35
Citations - 1129
Sylwia Huber is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Alpha-synuclein & Medicine. The author has an hindex of 13, co-authored 30 publications receiving 748 citations. Previous affiliations of Sylwia Huber include Bielefeld University.
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Journal ArticleDOI
Structure of the Acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1
Roger J. P. Dawson,Jörg Benz,Peter Stohler,Tim Tetaz,Catherine Joseph,Sylwia Huber,Georg Schmid,Daniela Hügin,Pascal Pflimlin,Gerd Trube,Markus G. Rudolph,Michael Hennig,Armin Ruf +12 more
TL;DR: The results provide a general concept for gating modifier toxin binding suggesting that both surface motifs are required to modify the gating characteristics of an ion channel.
Journal ArticleDOI
Synthetic single domain antibodies for the conformational trapping of membrane proteins
Iwan Zimmermann,Pascal Egloff,Cedric A. J. Hutter,Fabian M. Arnold,Peter Stohler,Nicolas Bocquet,Melanie N. Hug,Sylwia Huber,Martin Siegrist,Lisa Hetemann,Jeniffer Gera,Samira Gmuer,Peter Spies,Daniel Gygax,Eric R. Geertsma,Roger J. P. Dawson,Markus A. Seeger +16 more
TL;DR: An in vitro selection platform based on synthetic single domain antibodies named sybodies, designed to target the limited hydrophilic surfaces of membrane proteins, and designed three sybody libraries that exhibit different shapes and moderate hydrophobicity of the randomized surface.
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Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers
Manaswini Sivaramakrishnan,Manaswini Sivaramakrishnan,Kathleen D. McCarthy,Sébastien Campagne,Sylwia Huber,Sonja Meier,Sonja Meier,Angélique Augustin,Tobias Heckel,Hélène Meistermann,Melanie N. Hug,Pascale Birrer,Ahmed Moursy,Sarah Khawaja,Roland Schmucki,Nikos Berntenis,Nicolas Giroud,Sabrina Golling,Manuel Tzouros,Balazs Banfai,Gonzalo Duran-Pacheco,Jens Lamerz,Ying Hsiu Liu,Thomas Luebbers,Hasane Ratni,Martin Ebeling,Antoine Cléry,Sergey Paushkin,Adrian R. Krainer,Frédéric H.-T. Allain,Friedrich Metzger +30 more
TL;DR: Evidence is provided that SMN2 mRNA forms a ribonucleoprotein complex that can be specifically targeted by these small molecules, and has wide-ranging implications in understanding how small molecules can interact with specific quaternary RNA structures.
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Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ5-integrin–integrin linked kinase signalling complex
Tobias Wiedemann,Stefan Hofbaur,Nicole Tegtmeyer,Sylwia Huber,Norbert Sewald,Silja Wessler,Steffen Backert,Gabriele Rieder +7 more
TL;DR: The newly discovered recognition receptor complex could be a useful target in treating precancerous conditions triggered by H pylori induced hypergastrinaemia.
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DNA-encoded library-derived DDR1 inhibitor prevents fibrosis and renal function loss in a genetic mouse model of Alport syndrome.
Hans Richter,Alexander L. Satz,Marc Bedoucha,Bernd Buettelmann,Ann C. Petersen,Anja Harmeier,Ricardo Hermosilla,Remo Hochstrasser,Dominique Burger,Bernard Gsell,Rodolfo Gasser,Sylwia Huber,Melanie N. Hug,Buelent Kocer,Bernd Kuhn,Martin Ritter,Markus G. Rudolph,Franziska Weibel,Judith Molina-David,Jin Ju Kim,Javier Varona Santos,Martine Stihle,Guy Georges,R. Daniel Bonfil,Rafael Fridman,Sabine Uhles,Solange Moll,Christian Faul,Alessia Fornoni,Marco Prunotto,Marco Prunotto +30 more
TL;DR: Compound 2.45 preserves renal function and reduces tissue damage in Col4a3–/– mice (the preclinical mouse model of Alport syndrome) when employing a therapeutic dosing regime, indicating the real therapeutic value of selectively inhibiting DDR1 phosphorylation in vivo.