Péter Szelényi

TL;DR: HNE-mediated signaling can largely influence the fate of the cell through modulating major cellular processes, such as autophagy, proliferation and apoptosis, and the role of HNE in the pathophysiology of cancer, cardiovascular and neurodegenerative diseases is discussed.

TL;DR: Findings have substantiated the lipotoxic liver injury hypothesis for the pathomechanism of hepatosteatosis and the involvement of endoplasmic reticulum stress responses and focused on the metabolic and redox aspects of lipotoxicity and lipoapoptosis.

TL;DR: The results suggest that cytosolic F6P promotes prereceptor glucocorticoid activation in white adipose tissue, which might have a role in the pathophysiology of the metabolic syndrome.

TL;DR: Important metabolic characteristics of TFAs are revealed that might underlie a long term toxicity and hence deserve further investigation, including correlation between the accumulation of lipid intermediates and the severity of cell damage.

TL;DR: Evidence is presented for the biologic actions of tea flavan-3-ols on specific ER targets associated with normal function and disease and the mechanisms likely contribute to the chemopreventive and glucose-lowering effects of tea catechins.