P
Peter Verhasselt
Researcher at Janssen Pharmaceutica
Publications - 39
Citations - 4644
Peter Verhasselt is an academic researcher from Janssen Pharmaceutica. The author has contributed to research in topics: Gene & Receptor. The author has an hindex of 25, co-authored 39 publications receiving 4328 citations. Previous affiliations of Peter Verhasselt include Johnson & Johnson Pharmaceutical Research and Development.
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Journal ArticleDOI
A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis.
Koen Andries,Peter Verhasselt,Jerome Guillemont,Hinrich W. H. Göhlmann,Jean-Marc Neefs,Hans Winkler,Jef Van Gestel,Philip Timmerman,Min Zhu,Ennis Lee,Peter Williams,Didier de Chaffoy,Emma Huitric,Sven Hoffner,Emmanuelle Cambau,Chantal Truffot-Pernot,Nacer Lounis,Vincent Jarlier +17 more
TL;DR: A diarylquinoline, R207910, is identified that potently inhibits both drug-sensitive and drug-resistant Mycobacterium tuberculosis in vitro and mutants selected in vitro suggest that the drug targets the proton pump of adenosine triphosphate (ATP) synthase.
Journal ArticleDOI
Contribution of mutations in the cytochrome P450 14α-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans
Patrick Marichal,Patrick Marichal,Luc Koymans,Staf Willemsens,D. Bellens,Peter Verhasselt,Walter Luyten,Marcel Borgers,Frans C. S. Ramaekers,Frank C. Odds,Hugo Vanden Bossche +10 more
TL;DR: The cytochrome P450 14alpha-demethylase, encoded by the ERG11 (CYP51) gene, is the primary target for the azole class of antifungals and mutations found in the two N-terminal regions only Y132H was demonstrated to be of importance for azole resistance.
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Genetic variations of KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 in drug-induced long QT syndrome patients.
Aimee D C Paulussen,Ronaldus A. H. J. Gilissen,Martin Armstrong,Pieter A. Doevendans,Peter Verhasselt,Hubert J.M. Smeets,Eric Schulze-Bahr,Wilhelm Haverkamp,Giinter Breithardt,Nadine Cohen,Jeroen Aerssens +10 more
TL;DR: It is concluded that missense mutations in the examined cLQ TS genes explain only a minority of aLQTS cases, and are thus unlikely to significantly influence aL QTS susceptibility.
Journal ArticleDOI
Rates and Mechanisms of Resistance Development in Mycobacterium tuberculosis to a Novel Diarylquinoline ATP Synthase Inhibitor
Emma Huitric,Emma Huitric,Peter Verhasselt,Anil Koul,Koen Andries,Sven Hoffner,Sven Hoffner,Dan I. Andersson +7 more
TL;DR: Ninety-seven independent R207910-resistant mutants were selected from seven different clinical isolates of M. tuberculosis and the atpE gene, which encodes a transmembrane and oligomeric C subunit of the ATP synthase and which was previously shown to be involved in resistance, was sequenced.
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Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3.
Stefan Masure,Burkhard Haefner,Jan-Jaap Wesselink,Hoefnagel Evert Wilhelmus,Eva Mortier,Peter Verhasselt,An Tuytelaars,Robert Gordon,Alan Richardson +8 more
TL;DR: Akt-3 is a promising target for the discovery of novel chemotherapeutic agents which do not interfere with insulin signalling, but is not highly expressed in liver or skeletal muscle, suggesting that its principle function may not be in regulating insulin signalling.