P
Petra Clowes
Researcher at Ludwig Maximilian University of Munich
Publications - 41
Citations - 1967
Petra Clowes is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Tuberculosis & Population. The author has an hindex of 21, co-authored 39 publications receiving 1675 citations. Previous affiliations of Petra Clowes include National Institute for Medical Research.
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Journal ArticleDOI
Feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing for tuberculosis in primary-care settings in Africa: a multicentre, randomised, controlled trial
Grant Theron,Lynn S. Zijenah,Duncan Chanda,Petra Clowes,Petra Clowes,Andrea Rachow,Maia Lesosky,Wilbert Bara,Stanley Mungofa,Madhukar Pai,Michael Hoelscher,David W. Dowdy,Alexander S. Pym,Peter Mwaba,Peter R. Mason,Jonny Peter,Keertan Dheda +16 more
TL;DR: The feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing at primary-care health-care facilities in southern Africa, and the primary outcome was tuberculosis-related morbidity in culture-positive patients who had begun anti-tuberculosis treatment.
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Effect on mortality of point-of-care, urine-based lipoarabinomannan testing to guide tuberculosis treatment initiation in HIV-positive hospital inpatients: a pragmatic, parallel-group, multicountry, open-label, randomised controlled trial
Jonny Peter,Lynn S. Zijenah,Duncan Chanda,Duncan Chanda,Petra Clowes,Petra Clowes,Maia Lesosky,Phindile Gina,Nirja Mehta,Greg Calligaro,Carl Lombard,Gerard Kadzirange,Tsitsi Bandason,Abidan Chansa,Namakando Liusha,Chacha Mangu,Bariki Mtafya,Bariki Mtafya,Henry Msila,Andrea Rachow,Andrea Rachow,Michael Hoelscher,Michael Hoelscher,Peter Mwaba,Grant Theron,Grant Theron,Keertan Dheda +26 more
TL;DR: The implementation of LAM testing is likely to offer the greatest benefit in hospitals where diagnostic resources are most scarce and where patients present with severe illness, advanced immunosuppression, and an inability to self-expectorate sputum.
Journal ArticleDOI
Increased and Expedited Case Detection by Xpert MTB/RIF Assay in Childhood Tuberculosis: A Prospective Cohort Study
Andrea Rachow,Petra Clowes,Petra Clowes,Elmar Saathoff,Bariki Mtafya,Epiphania Michael,Elias N. Ntinginya,Dickens Kowour,Gabriel Rojas-Ponce,Arne Kroidl,Arne Kroidl,Leonard Maboko,Norbert Heinrich,Klaus Reither,Klaus Reither,Klaus Reither,Michael Hoelscher +16 more
TL;DR: Xpert was easy to perform and displayed similar diagnostic accuracy as culture methods in children with suspected tuberculosis in a high tuberculosis/HIV-burden setting, although sensitivity remains suboptimal and access is dependent on local laboratory infrastructure.
Journal ArticleDOI
Assessment of the Xpert MTB/RIF assay for diagnosis of tuberculosis with gastric lavage aspirates in children in sub-Saharan Africa: a prospective descriptive study.
Matthew Bates,Justin O'Grady,Markus Maeurer,John Tembo,Lophina Chilukutu,Chishala Chabala,Richard Kasonde,Peter Mulota,Judith Mzyece,Mumba Chomba,Lukundo Mukonda,Maxwell Mumba,Nathan Kapata,Nathan Kapata,Andrea Rachow,Petra Clowes,Michael Hoelscher,Peter Mwaba,Peter Mwaba,Alimuddin Zumla +19 more
TL;DR: The sensitivity and specificity of the Xpert MTB/RIF assay with GLA samples for the detection of pulmonary tuberculosis and MDR tuberculosis in new paediatric inpatient admissions at the University Teaching Hospital, Lusaka, Zambia were similar.
Journal ArticleDOI
Assessment of the novel T-cell activation marker–tuberculosis assay for diagnosis of active tuberculosis in children: a prospective proof-of-concept study
Damien Portevin,Damien Portevin,Felicien Moukambi,Petra Clowes,Asli Bauer,Mkunde Chachage,Nyanda E. Ntinginya,Elirehema Mfinanga,Khadija Said,Frederick Haraka,Andrea Rachow,Elmar Saathoff,Maximilian Mpina,Levan Jugheli,Levan Jugheli,Levan Jugheli,Fred Lwilla,Ben J. Marais,Michael Hoelscher,Claudia Daubenberger,Claudia Daubenberger,Klaus Reither,Klaus Reither,Klaus Reither,Christof Geldmacher +24 more
TL;DR: The sputum-independent TAM-TB assay is a rapid and accurate blood test that has the potential to improve the diagnosis of active tuberculosis in children.