G
Guy E. Thwaites
Researcher at University of Oxford
Publications - 479
Citations - 26499
Guy E. Thwaites is an academic researcher from University of Oxford. The author has contributed to research in topics: Tuberculous meningitis & Population. The author has an hindex of 66, co-authored 431 publications receiving 18302 citations. Previous affiliations of Guy E. Thwaites include Guy's and St Thomas' NHS Foundation Trust & National Health Service.
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Journal ArticleDOI
Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis.
Evelina Tacconelli,Elena Carrara,Alessia Savoldi,Stéphan Juergen Harbarth,Marc Mendelson,Dominique L Monnet,Céline Pulcini,Gunnar Kahlmeter,Jan Kluytmans,Yehuda Carmeli,Marc Ouellette,Kevin Outterson,Jean B. Patel,Marco Cavaleri,Edward Cox,Christopher R. Houchens,M Lindsay Grayson,Paul Hansen,Nalini Singh,Ursula Theuretzbacher,Nicola Magrini,Aaron O. Aboderin,Seif Al-Abri,Nordiah Awang Jalil,Nur Benzonana,Sanjay Bhattacharya,Adrian Brink,Francesco Robert Burkert,Otto Cars,Giuseppe Cornaglia,Oliver J. Dyar,Alexander W. Friedrich,Ana Cristina Gales,Sumanth Gandra,Christian G. Giske,Debra A. Goff,Herman Goossens,Thomas Gottlieb,Manuel Guzman Blanco,Waleria Hryniewicz,Deepthi Kattula,Timothy Jinks,Souha S. Kanj,Lawrence Kerr,Marie-Paule Kieny,Yang Soo Kim,Roman S. Kozlov,Jaime Labarca,Ramanan Laxminarayan,Karin Leder,Leonard Leibovici,Gabriel Levy-Hara,Jasper Littman,Surbhi Malhotra-Kumar,Vikas Manchanda,Lorenzo Moja,Babacar Ndoye,Angelo Pan,David L. Paterson,Mical Paul,Haibo Qiu,Pilar Ramon-Pardo,Jesús Rodríguez-Baño,Maurizio Sanguinetti,Sharmila Sengupta,Mike Sharland,Massinissa Si-Mehand,Lynn L. Silver,Wonkeung Song,Martin Steinbakk,Jens Thomsen,Guy E. Thwaites,Jos W. M. van der Meer,Nguyen Van Kinh,Silvio Vega,Maria Virginia Villegas,Agnes Wechsler-Fördös,Heiman F. L. Wertheim,Evelyn Wesangula,Neil Woodford,Fidan O Yilmaz,Anna Zorzet +81 more
TL;DR: Future development strategies should focus on antibiotics that are active against multidrug-resistant tuberculosis and Gram-negative bacteria, and include antibiotic-resistant bacteria responsible for community-acquired infections.
Journal ArticleDOI
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis
Christopher J L Murray,Kevin S Ikuta,Fablina Sharara,Lucien Swetschinski,Gisela Robles Aguilar,Authia Gray,Chieh Fei Han,Catherine Bisignano,Puja C Rao,Eve E. Wool,Sarah Charlotte Johnson,Annie J. Browne,Michael G. Chipeta,Frederick Fell,Sean Hackett,Georgina Haines-Woodhouse,Bahar H. Kashef Hamadani,Emmanuelle A. P. Kumaran,Barney McManigal,Sureeruk Achalapong,Ramesh Agarwal,Samuel Akech,Samuel B. Albertson,John H Amuasi,Jason R. Andrews,Aleskandr Aravkin,Elizabeth A. Ashley,François-Xavier Babin,Freddie Bailey,Stephen Baker,Buddha Basnyat,Adrie Bekker,Rose G Bender,James A. Berkley,Adhisivam Bethou,Julia Bielicki,Suppawat Boonkasidecha,James Bukosia,Cristina Gardony Carvalheiro,Carlos A Castañeda-Orjuela,Vilada Chansamouth,Suman Chaurasia,Sara Chiurchiù,Fazle Rabbi Chowdhury,Rafai Clotaire Donatien,Aislinn Cook,Ben S. Cooper,Tim R. Cressey,Elia Criollo-Mora,Matthew Cunningham,Saffiatou Darboe,Nicholas P. J. Day,Maia De Luca,Klara Dokova,Angela Dramowski,Susanna Dunachie,Thuy Duong Bich,Tim Eckmanns,Daniel Eibach,Amir Emami,Nicholas A. Feasey,Natasha Fisher-Pearson,Karen Forrest,Coralith Garcia,Denise O Garrett,Petra Gastmeier,Ababi Zergaw Giref,Rachel C Greer,Vikas Gupta,Sebastian Haller,Andrea Haselbeck,Simon I. Hay,M. Holm,Susan Hopkins,Yingfen Hsia,Kenneth Iregbu,Jan Jacobs,Daniel Jarovsky,Fatemeh Javanmardi,Adam Jenney,Meera Khorana,Suwimon Khusuwan,Niranjan Kissoon,Elsa Kobeissi,Tomislav Kostyanev,Fiorella Krapp,Ralf Krumkamp,Ajay Kumar,Hmwe H Kyu,Cherry Lim,Kruy Lim,Direk Limmathurotsakul,Michael J. Loftus,Miles Lunn,Jianing Ma,Anand Manoharan,Florian Marks,Jürgen May,Mayfong Mayxay,Neema Mturi,Tatiana Múnera-Huertas,Patrick Musicha,Lilian Musila,Marisa Márcia Mussi-Pinhata,Ravi Naidu,Tomoka Nakamura,Ruchi Nanavati,Sushma Nangia,Paul N. Newton,Chanpheaktra Ngoun,Amanda Novotney,Davis Nwakanma,Christina W. Obiero,Theresa J. Ochoa,Antonio Olivas-Martinez,Piero Olliaro,Edna Ooko,Edgar Ortiz-Brizuela,Pradthana Ounchanum,Gi Deok Pak,Jose Luis Paredes,Anton Y. Peleg,Carlo Perrone,Thong Phe,Koukeo Phommasone,Nishad Plakkal,Alfredo Ponce-de-León,Mathieu Raad,Tanusha Ramdin,Sayaphet Rattanavong,Amy Riddell,Tamalee Roberts,Julie V. Robotham,Anna Roca,Victor D. Rosenthal,Kristina E. Rudd,Neal Russell,Helio S. Sader,Weerawut Saengchan,Janice W. Schnall,John Anthony G Scott,Samroeng Seekaew,Mike Sharland,Madhusudhan Shivamallappa,José Sifuentes-Osornio,A. John Simpson,Nicolas Steenkeste,Andrew J. Stewardson,Temenuga Stoeva,Nidanuch Tasak,Areerat Thaiprakong,Guy E. Thwaites,Caroline Tigoi,Claudia Turner,Paul Turner,H. Rogier van Doorn,Sithembiso Velaphi,Avina Vongpradith,Manivanh Vongsouvath,Huong X. Vu,Timothy R. Walsh,Judd L. Walson,Seymour Waner,Tri Wangrangsimakul,Prapass Wannapinij,Teresa M. Wozniak,Tracey E M W Young Sharma,Kalvin C. Yu,Peng Zheng,Benn Sartorius,Alan D. Lopez,Andy Stergachis,Catrin E. Moore,Christiane Dolecek,Mohsen Naghavi +174 more
TL;DR: This study provides the first comprehensive assessment of the global burden of AMR, as well as an evaluation of the availability of data, and estimates aggregated to the global and regional level.
Journal ArticleDOI
Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans
Iñaki Comas,Mireia Coscolla,Mireia Coscolla,Tao Luo,Sonia Borrell,Sonia Borrell,Kathryn E. Holt,Midori Kato-Maeda,Julian Parkhill,Bijaya Malla,Bijaya Malla,Stefan Berg,Guy E. Thwaites,Dorothy Yeboah-Manu,Graham H. Bothamley,Jian Mei,Lan-Hai Wei,Stephen D. Bentley,Simon R. Harris,Stefan Niemann,Roland Diel,Abraham Aseffa,Qian Gao,Douglas B. Young,Douglas B. Young,Sebastien Gagneux,Sebastien Gagneux +26 more
TL;DR: Coalescent analyses indicate that MTBC emerged about 70,000 years ago, accompanied migrations of anatomically modern humans out of Africa and expanded as a consequence of increases in human population density during the Neolithic period, consistent with MTBC displaying characteristics indicative of adaptation to both low and high host densities.
Journal ArticleDOI
Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults.
Guy E. Thwaites,Nguyen Db,Nguyen Hd,Hoang Tq,Do Tt,Nguyen Tc,Nguyen Qh,Nguyen Tt,Nguyen Nh,Nguyen Tn,Nguyen Nl,Vu Nt,Cao Hh,Tinh Hien Tran,Pham Pm,T D Nguyen,Kasia Stepniewska,Nicholas J. White,Jeremy Farrar +18 more
TL;DR: Adjunctive treatment with dexamethasone improves survival in patients over 14 years of age with tuberculous meningitis but probably does not prevent severe disability.
Journal ArticleDOI
Tuberculous meningitis: a uniform case definition for use in clinical research
Suzaan Marais,Guy E. Thwaites,Johan F. Schoeman,M. Estée Török,Usha K. Misra,Kameshwar Prasad,Peter R. Donald,Robert J. Wilkinson,Ben J. Marais +8 more
TL;DR: A writing committee was appointed to finalise a consensus case definition for tuberculous meningitis for use in future clinical research and this case definition is applicable irrespective of the patient's age, HIV infection status, or the resources available in the research setting.