T
Tineke Schollaardt
Researcher at University of Calgary
Publications - 6
Citations - 725
Tineke Schollaardt is an academic researcher from University of Calgary. The author has contributed to research in topics: Cell adhesion molecule & Cytokine. The author has an hindex of 5, co-authored 6 publications receiving 688 citations. Previous affiliations of Tineke Schollaardt include Mahidol University.
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Journal ArticleDOI
The Prognostic and Pathophysiologic Role of Pro- and Antiinflammatory Cytokines in Severe Malaria
Nicholas P. J. Day,Tran Tinh Hien,Tineke Schollaardt,Pham Phu Loc,Ly Van Chuong,Tran Thi Hong Chau,Nguyen Thi Hoang Mai,Nguyen Hoan Phu,Dinh Xuan Sinh,Nicholas J. White,Nicholas J. White,May Ho +11 more
TL;DR: Elevated plasma cytokines in severe malaria are associated with systemic pathologic abnormalities, not cerebral involvement, and both the overall magnitude of the cytokine responses and the eventual imbalance between the pro- and antiinflammatory responses are important determinants of mortality.
Journal ArticleDOI
Synergism of multiple adhesion molecules in mediating cytoadherence of Plasmodium falciparum–infected erythrocytes to microvascular endothelial cells under flow
Bryan G. Yipp,Samantha Anand,Samantha Anand,Tineke Schollaardt,Tineke Schollaardt,Kamala D. Patel,Kamala D. Patel,Sornchai Looareesuwan,Sornchai Looareesuwan,May Ho,May Ho +10 more
TL;DR: Findings indicate that IRBCs interact synergistically with multiple adhesion molecules on vascular endothelium, since it can be modulated by cytokines to enhance CD36-mediated IRBC adhesion.
Journal ArticleDOI
Endogenous interleukin-10 modulates proinflammatory response in Plasmodium falciparum malaria.
May Ho,Tineke Schollaardt,Susan Snape,Sornchai Looareesuwan,Pravan Suntharasamai,Nicholas J. White +5 more
TL;DR: Findings suggest that IL-10 counter-regulates the proinflammatory response to P. falciparum malaria, which may be associated with an inadequate negative feedback response byIL-10.
Journal ArticleDOI
Characterization of Plasmodium falciparum -Infected Erythrocyte and P-Selectin Interaction Under Flow Conditions
May Ho,May Ho,Tineke Schollaardt,Tineke Schollaardt,Xiao-Fei Niu,Xiao-Fei Niu,Sornchai Looareesuwan,Sornchai Looareesuwan,Kamala D. Patel,Kamala D. Patel,Paul Kubes,Paul Kubes +11 more
TL;DR: Investigation of the molecular interactions between IRBC and P-selectin using a laminar flow system showed that cytoadherence under physiological flow conditions may be mediated by multiple IRBC ligands that interact with different adhesion molecules in a cooperative fashion.
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Efficacy of oral immunization with Pseudomonas aeruginosa lipopolysaccharide
TL;DR: Protection against P. aeruginosa in an ironloaded mouse model and a burned mouse model of infection was achieved and passive transfer experiments demonstrated that protection was associated with specific antibody and not by cell mediated immunity.