Philip A. Wood

TL;DR: It is reported for the first time that impaired but not abolished NF-κB signaling in humans results in two related syndromes that associate specific developmental and immunological defects.

TL;DR: It is shown that LCAD knockout mice develop hepatic steatosis, which is associated with hepatic insulin resistance, as reflected by reduced insulin suppression of hepatic glucose production during a hyperinsulinemic-euglycemic clamp, and primary defects in mitochondrial fatty acid oxidation capacity can lead to diacylglycerol accumulation, PKCε activation, and hepatic diabetes.

TL;DR: The results demonstrate the crucial roles of mitochondrial FAO and LCAD in vivo and show frequent gestational loss in mice model of LCAD deficiency with severely impaired FAO.

TL;DR: CPT1b deficiency can cause lipotoxicity in the heart under pathological stress, leading to exacerbation of cardiac pathology, and caution should be exercised in the clinical use of CPT1 inhibitors.

TL;DR: An underappreciated metabolic pathway involving fatty acid β-oxidation also regulates theta oscillations during sleep, and Acads expression in brain regions involved in theta generation, notably the hippocampus is found.