D
Denis J. Headon
Researcher at University of Edinburgh
Publications - 73
Citations - 5172
Denis J. Headon is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Edar Receptor & Hair follicle. The author has an hindex of 30, co-authored 68 publications receiving 4591 citations. Previous affiliations of Denis J. Headon include Case Western Reserve University & Baylor College of Medicine.
Papers
More filters
Journal ArticleDOI
X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling.
Rainer Doffinger,Asma Smahi,Christine Bessia,Frederic Geissmann,Jacqueline Feinberg,Anne Durandy,Christine Bodemer,Sue Kenwrick,Sophie Dupuis-Girod,Stéphane Blanche,Philip A. Wood,Smail Hadj Rabia,Denis J. Headon,Paul A. Overbeek,Françoise Le Deist,Steven M. Holland,Kiran Belani,Dinakantha S. Kumararatne,Alain Fischer,Ralph S. Shapiro,Mary Ellen Conley,Eric Reimund,Hermann Kalhoff,Mario Abinun,Arnold Munnich,Alain Israël,Gilles Courtois,Jean-Laurent Casanova +27 more
TL;DR: It is reported for the first time that impaired but not abolished NF-κB signaling in humans results in two related syndromes that associate specific developmental and immunological defects.
Journal ArticleDOI
Involvement of a novel Tnf receptor homologue in hair follicle induction.
Denis J. Headon,Paul A. Overbeek +1 more
TL;DR: The positional cloning of the dl gene is reported, which encodes a novel member of the tumour necrosis factor (Tnf) receptor ( Tnfr) family, and the mutant phenotype and dl expression pattern suggests that this gene encode a receptor that specifies hair follicle fate.
Journal ArticleDOI
Mutations in the human homologue of mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasia
Alex W. Monreal,Betsy Ferguson,Denis J. Headon,Summer L. Street,Paul A. Overbeek,Jonathan Zonana +5 more
TL;DR: X-linked hypohidrotic ectodermal dysplasia results in abnormal morphogenesis of teeth, hair and eccrine sweat glands, and the gene (ED1) responsible for the disorder has been identified, as well as the analogous X-linked gene in the mouse.
Journal ArticleDOI
Gene defect in ectodermal dysplasia implicates a death domain adapter in development.
Denis J. Headon,Stephanie A. Emmal,Betsy Ferguson,Abigail S. Tucker,Monica J. Justice,Paul T. Sharpe,Jonathan Zonana,Paul A. Overbeek +7 more
TL;DR: The findings show that the death receptor/adapter signalling mechanism is conserved in developmental, as well as apoptotic, signalling.
Journal ArticleDOI
A Link Between mRNA Turnover and RNA Interference in Arabidopsis
S. Gazzani,T. Lawrenson,T. Lawrenson,T. Lawrenson,C. Woodward,C. Woodward,C. Woodward,Denis J. Headon,Robert Sablowski,Robert Sablowski,Robert Sablowski +10 more
TL;DR: It is proposed that mRNAs lacking a cap structure become exposed to RdRp to initiate or maintain RNAi, and it is shown that RdRP-dependent transgene silencing in Arabidopsis was caused by mutation of XRN4.