P
Philip J. Cowen
Researcher at University of Oxford
Publications - 507
Citations - 30646
Philip J. Cowen is an academic researcher from University of Oxford. The author has contributed to research in topics: Antidepressant & Serotonin. The author has an hindex of 85, co-authored 506 publications receiving 28107 citations. Previous affiliations of Philip J. Cowen include Warneford Hospital & Manchester Mental Health and Social Care Trust.
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Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group
Lianne Schmaal,Dick J. Veltman,T.G.M. van Erp,Philipp G. Sämann,Thomas Frodl,Neda Jahanshad,Elizabeth Loehrer,Henning Tiemeier,A. Hofman,Wiro J. Niessen,Meike W. Vernooij,M. A. Ikram,Katharina Wittfeld,Hans-Jörgen Grabe,Andrea Block,K Hegenscheid,Henry Völzke,D. Hoehn,Michael Czisch,Jim Lagopoulos,Sean N. Hatton,Ian B. Hickie,Roberto Goya-Maldonado,Bernhard K. Krämer,Oliver Gruber,Baptiste Couvy-Duchesne,Miguel E. Rentería,Lachlan T. Strike,Natalie T. Mills,G. I. de Zubicaray,Katie L. McMahon,Sarah E. Medland,Nicholas G. Martin,Nathan A. Gillespie,Margaret J. Wright,Geoffrey B. Hall,Glenda MacQueen,Eva-Maria Frey,Angela Carballedo,L. S. van Velzen,M.J.D. van Tol,N.J. van der Wee,Ilya M. Veer,Henrik Walter,Knut Schnell,Elisabeth Schramm,Claus Normann,D. Schoepf,Carsten Konrad,Bartosz Zurowski,Thomas Nickson,Andrew M. McIntosh,Martina Papmeyer,Heather C. Whalley,J.E. Sussmann,Beata R. Godlewska,Philip J. Cowen,Felix Fischer,Matthias Rose,Brenda W.J.H. Penninx,Paul M. Thompson,D. P. Hibar +61 more
TL;DR: In this paper, the authors meta-analyzed three-dimensional brain magnetic resonance imaging data from 1728 major depressive disorder (MDD) patients and 7199 controls from 15 research samples worldwide, to identify subcortical brain volumes that robustly discriminate MDD patients from healthy controls.
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Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment
Peter A. Sargent,Karen Husted Kjaer,Christopher J. Bench,Eugenii A. Rabiner,Cristina Messa,Jeffrey H. Meyer,Roger N. Gunn,Paul M. Grasby,Philip J. Cowen +8 more
TL;DR: Binding potential values were reduced across many of the regions examined, including frontal, temporal, and limbic cortex in both unmedicated and medicated depressed patients compared with healthy volunteers.
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Direct radioimmunoassay for melatonin in plasma.
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Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2000 British Association for Psychopharmacology guidelines
Ian M. Anderson,I. N. Ferrier,RC Baldwin,Philip J. Cowen,Louise M. Howard,Glyn Lewis,Keith Matthews,RH McAllister-Williams,Robert Peveler,Jan Scott,Andre Tylee +10 more
TL;DR: These guidelines cover the nature and detection of depressive disorders, acute treatment with antidepressant drugs, choice of drug versus alternative treatment, practical issues in prescribing and management, next-step treatment, relapse prevention, treatment of relapse, and stopping treatment.
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Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition.
TL;DR: Short-term administration of two different antidepressant types had similar effects on emotion-related tasks in healthy volunteers, reducing the processing of negative relative to positive emotional material and suggesting a mechanism of action potentially compatible with cognitive theories of anxiety and depression.