P
Philip K. Moore
Researcher at National University of Singapore
Publications - 169
Citations - 20762
Philip K. Moore is an academic researcher from National University of Singapore. The author has contributed to research in topics: Nitric oxide & Nitric oxide synthase. The author has an hindex of 74, co-authored 169 publications receiving 19111 citations. Previous affiliations of Philip K. Moore include Barts Health NHS Trust & Yale-NUS College.
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Journal ArticleDOI
Hydrogen Sulfide and Cell Signaling
TL;DR: Pharmacological experiments using H₂S donors and genetic experiments using CSE knockout mice suggest important roles for this vasodilator gas in the regulation of blood vessel caliber, cardiac response to ischemia/reperfusion injury, and inflammation.
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L-NG-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro.
TL;DR: The available data suggests that l‐NOARG, like l‐NMMA, inhibits endothelial nitric oxide (NO) biosynthesis and is identified as a potent, l‐arginine reversible inhibitor of endothelium‐dependent vasodilatation.
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Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse
Ling Li,Madhav Bhatia,Yi Zhun Zhu,Yi Chun Zhu,Raina Devi Ramnath,Zhong Jing Wang,Farhana Anuar,Matthew Whiteman,Manuel Salto-Tellez,Philip K. Moore +9 more
TL;DR: It is suggested that H2S exhibits proinflammatory activity in endotoxic shock and a new approach to the development of novel drugs for this condition is suggested.
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Characterization of a Novel, Water-Soluble Hydrogen Sulfide–Releasing Molecule (GYY4137): New Insights Into the Biology of Hydrogen Sulfide
Ling Li,Matthew Whiteman,Yan Yi Guan,Kay Li Neo,Yvonne Cheng,Shiau Wei Lee,Yujun Zhao,Rajamanian Baskar,Choon-Hong Tan,Philip K. Moore +9 more
TL;DR: The results identify GYY4137 as a slow-releasing H2S compound with vasodilator and antihypertensive activity that is likely to prove useful in the study of the many and varied biological effects of H1N1.
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The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite ‘scavenger’?
Matthew Whiteman,Jeffrey S. Armstrong,Siew Hwa Chu,Siau Jia-Ling,Boon Seng Wong,Nam Sang Cheung,Barry Halliwell,Philip K. Moore +7 more
TL;DR: H2S has the potential to act as an inhibitor of peroxynitrite‐mediated processes in vivo and that the potential antioxidant action of H2S deserves further study, given that extracellular GSH levels in the brain are very low.