P
Philip K. Moore
Researcher at National University of Singapore
Publications - 169
Citations - 20762
Philip K. Moore is an academic researcher from National University of Singapore. The author has contributed to research in topics: Nitric oxide & Nitric oxide synthase. The author has an hindex of 74, co-authored 169 publications receiving 19111 citations. Previous affiliations of Philip K. Moore include Barts Health NHS Trust & Yale-NUS College.
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Morpholin-4-ium 4 methoxyphenyl (morpholino) phosphinodithioate (GYY4137) as a novel vasodilator agent
TL;DR: In this article, a method of administering hydrogen sulfide slowly and sustainably to an individual in need thereof comprising administering an effective amount of a compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof.
Journal ArticleDOI
P073. Hydrogen sulfide regulates the availability of nitric oxide through the formation of a novel nitrosothiol: Implications for cardiovascular function and human disease
Matthew Whiteman,Muhammed Yusuf Ali,Ling Li,Yoke Ping Cheong,Ying-Yuan Pamela Mok,Iouri Kostetski,Siew Hwa Chu,Jia Ling Siau,Madhav Bhatia,Philip K. Moore +9 more
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Discovery of medium ring thiophosphorus based heterocycles as antiproliferative agents.
Wei Feng,Wisna Novera,Kaye Peh,Donavan Neo,Pondy Murugappan Ramanujulu,Philip K. Moore,Lih-Wen Deng,Brian W. Dymock +7 more
TL;DR: A seven membered ring compound, 17, was found to be the most potent with sub-micromolar IC50s in breast and ovarian cancer cell lines, and comparison with its non-sulfur oxygen analogue, 26, provided evidence that the sulfur atom is important for its potency.
Journal ArticleDOI
Multifaceted role of nitric oxide in an in vitro mouse neuronal injury model: transcriptomic profiling defines the temporal recruitment of death signalling cascades
Zhao Feng Peng,Zhao Feng Peng,Minghui Jessica Chen,Jayapal Manikandan,Alirio J. Melendez,Guanghou Shui,Françoise Russo-Marie,Matthew Whiteman,Philip M Beart,Philip K. Moore,Nam Sang Cheung,Nam Sang Cheung +11 more
TL;DR: A detailed time‐course study of nitric oxide induced neuronal injury allowed us to provide the first time a holistic description of the temporal sequence of cellular events contributing to nitrergic injury.