P
Philip K. Moore
Researcher at National University of Singapore
Publications - 169
Citations - 20762
Philip K. Moore is an academic researcher from National University of Singapore. The author has contributed to research in topics: Nitric oxide & Nitric oxide synthase. The author has an hindex of 74, co-authored 169 publications receiving 19111 citations. Previous affiliations of Philip K. Moore include Barts Health NHS Trust & Yale-NUS College.
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Journal ArticleDOI
Role of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouse
TL;DR: The effect of inhibition of H(2)S formation and administration of NaHS suggests that H( 2)S plays a proinflammatory role in regulating the severity of sepsis and associated organ injury.
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Pharmacology and potential therapeutic applications of nitric oxide-releasing non-steroidal anti-inflammatory and related nitric oxide-donating drugs.
Julie Keeble,Philip K. Moore +1 more
TL;DR: The possibility that NO‐NSAID or NODD may be of therapeutic benefit in a wide variety of disease states including pain and inflammation, thrombosis and restenosis, neurodegenerative diseases of the central nervous system, colitis, cancer, urinary incontinence, liver disease, impotence, bronchial asthma and osteoporosis is discussed.
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Streptozotocin-induced diabetes in the rat is associated with enhanced tissue hydrogen sulfide biosynthesis.
Muhammed Yusuf,Benny Tan Kwong Huat,Annie Hsu,Matthew Whiteman,Madhav Bhatia,Philip K. Moore +5 more
TL;DR: The findings of this study suggest that the metabolism of H(2)S in pancreas and liver is altered in the streptozotocin-diabetic rat, the first study in which a derangement in H( 2)S biosynthesis in diabetes has been demonstrated.
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Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia
Marika Collin,Farhana Anuar,Oliver Murch,Madhav Bhatia,Philip K. Moore,Christoph Thiemermann +5 more
TL;DR: It is proposed that inhibition of H2S synthesis may be a useful therapeutic strategy against the organ injury associated with sepsis and shock.
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Hydrogen sulfide induces the synthesis of proinflammatory cytokines in human monocyte cell line U937 via the ERK‐NF‐κB pathway
TL;DR: These findings suggest for the first time that H2S stimulates the activation of human monocytes with the generation of proinflammatory cytokines, and this response is, at least partially, through the ERK‐NF‐κB signaling pathway.