P
Philip K. Moore
Researcher at National University of Singapore
Publications - 169
Citations - 20762
Philip K. Moore is an academic researcher from National University of Singapore. The author has contributed to research in topics: Nitric oxide & Nitric oxide synthase. The author has an hindex of 74, co-authored 169 publications receiving 19111 citations. Previous affiliations of Philip K. Moore include Barts Health NHS Trust & Yale-NUS College.
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Journal ArticleDOI
Mechanism of the inhibition of neuronal nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM)
R.L.C. Handy,Philip K. Moore +1 more
TL;DR: The present experiments suggest that 1-trifluoromethylphenyl imidazole interferes with the binding of both L-arginine and tetrahydrobiopterin to their respective sites on the nNOS enzyme.
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Metabolic stress is a primary pathogenic event in transgenic Caenorhabditis elegans expressing pan-neuronal human amyloid beta.
Emelyne Teo,Emelyne Teo,Sudharshan Ravi,Sudharshan Ravi,Diogo Barardo,Diogo Barardo,Hyung-Seok Kim,Sheng Fong,Amaury Cazenave-Gassiot,Tsze Yin Tan,Jianhong Ching,Jean-Paul Kovalik,Markus R. Wenk,Rudiyanto Gunawan,Philip K. Moore,Barry Halliwell,Nicholas S. Tolwinski,Jan Gruber,Jan Gruber +18 more
TL;DR: Treatment with an anti-diabetes drug, Metformin, reversed Aβ-induced metabolic defects, reduced protein aggregation and normalized lifespan of GRU102, and point to metabolic dysfunction as an early and causative event in A β-induced pathology and a promising target for intervention.
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Synergistic anti-nociceptive effect of L-NG-nitro arginine methyl ester (L-NAME) and flurbiprofen in the mouse.
TL;DR: It is suggested that l‐NAME and flurbiprofen/indomethacin act synergistically in their antinociceptive action in the mouse and may provide an alternative to the clinical control of pain in man.
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C. elegans aging is modulated by hydrogen sulfide and the sulfhydrylase/cysteine synthase cysl-2.
TL;DR: A mammalian cell culture system, GYY4137 was able to protect bovine aortic endothelial cells (BAECs) from oxidative stress and (H2O2)-induced cell death and provides further support that H2S exerts a protective function which is consistent with the longevity dividend theory.
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Hydrogen Sulfide As a Potential Target in Preventing Spermatogenic Failure and Testicular Dysfunction.
Jing Wang,Wan Wang,Shuangyue Li,Yi Han,Ping Zhang,Guoliang Meng,Yujiao Xiao,Liping Xie,Xin Wang,Jiahao Sha,Qi Chen,Philip K. Moore,Rui Wang,Wenpei Xiang,Yong Ji +14 more
TL;DR: These results provide the first indication that H2S is important for maintaining male fertility and protecting testicular function, mainly through the combination of anti-inflammatory and antioxidative effects.