Philip L. Leopold

TL;DR: It is proposed that activation of a SNAIL1–SMAD3/4 transcriptional complex represents a mechanism of gene repression during EMT, which is essential for organogenesis and is triggered during carcinoma progression to an invasive state.

TL;DR: Observations are consistent with the concept that upregulation of Shh activity in postnatal skin functions as a biologic switch that induces resting hair follicles to enter anagen with consequent hair growth.

TL;DR: Fluorescence ratio imaging revealed a neutral pH in the environment of translocating Ad, leading to a model in which the interaction of Ad with an intact microtubule cytoskeleton and functional cytoplasmic dynein occurs after escape from endosomes and is a necessary prerequisite to nuclear localization of adenovirus serotype 5.

TL;DR: Fluorescent labeling of virions provides a novel quantitative, morphological strategy to characterize the interaction of gene transfer vectors with the intracellular environment.

TL;DR: It is demonstrated that CAR deficiency on Ad targets can be circumvented either by supplying CAR or by modifying the Ad fiber to bind to other cell-surface receptors.