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Alexander Kukalev
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 25
Citations - 1381
Alexander Kukalev is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: RNA polymerase II & Gene. The author has an hindex of 12, co-authored 23 publications receiving 1173 citations. Previous affiliations of Alexander Kukalev include Imperial College London & Russian Academy of Sciences.
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Journal ArticleDOI
A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition.
Theresa Vincent,Theresa Vincent,Etienne P. A. Neve,Etienne P. A. Neve,Jill R. Johnson,Alexander Kukalev,Federico Rojo,Joan Albanell,Kristian Pietras,Ismo Virtanen,Lennart Philipson,Philip L. Leopold,Ronald G. Crystal,Antonio García de Herreros,Aristidis Moustakas,Ralf F. Pettersson,Jonas Fuxe +16 more
TL;DR: It is proposed that activation of a SNAIL1–SMAD3/4 transcriptional complex represents a mechanism of gene repression during EMT, which is essential for organogenesis and is triggered during carcinoma progression to an invasive state.
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Actin and hnRNP U cooperate for productive transcription by RNA polymerase II.
TL;DR: The results indicate that a general actin-based mechanism is implicated in the transcription of most Pol II genes and actin in complex with hnRNP U may carry out its regulatory role during the initial phases of transcription activation.
Journal ArticleDOI
The histone acetyltransferase PCAF associates with actin and hnRNP U for RNA polymerase II transcription.
Ales Obrdlik,Alexander Kukalev,Emilie Louvet,Ann-Kristin Östlund Farrants,Luca Caputo,Piergiorgio Percipalle +5 more
TL;DR: In this paper, the histone acetyltransferase (HAT) PCAF associates with actin and hnRNP U, and the nuclear actinassociated HAT activity detected in the DNase I-bound protein fraction could be released by disruption of the actin-hnRNPU complex.
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Cell-type specialization is encoded by specific chromatin topologies.
Warren Winick-Ng,Alexander Kukalev,Izabela Harabula,Izabela Harabula,Luna Zea-Redondo,Luna Zea-Redondo,Dominik Szabo,Dominik Szabo,Mandy Meijer,Leonid Serebreni,Leonid Serebreni,Yingnan Zhang,Simona Bianco,Andrea M. Chiariello,Ibai Irastorza-Azcarate,Christoph J. Thieme,Thomas M Sparks,Sílvia Carvalho,Luca Fiorillo,Francesco Musella,Ehsan Irani,Elena Torlai Triglia,Elena Torlai Triglia,Aleksandra A. Kolodziejczyk,Aleksandra A. Kolodziejczyk,Aleksandra A. Kolodziejczyk,Andreas Abentung,Andreas Abentung,Galina Apostolova,Eleanor J. Paul,Eleanor J. Paul,Vedran Franke,Rieke Kempfer,Rieke Kempfer,Altuna Akalin,Sarah A. Teichmann,Sarah A. Teichmann,Georg Dechant,Mark A. Ungless,Mario Nicodemi,Lonnie R. Welch,Gonçalo Castelo-Branco,Ana Pombo,Ana Pombo +43 more
TL;DR: In this article, an extension of genome architecture mapping (GAM) was developed to map 3D chromatin topology genome-wide in specific brain cell types, without tissue disruption, from single animals.
Journal ArticleDOI
RNA polymerase II primes Polycomb-repressed developmental genes throughout terminal neuronal differentiation
Carmelo Ferrai,Carmelo Ferrai,Elena Torlai Triglia,Jessica R. Risner-Janiczek,Tiago Rito,Owen J. L. Rackham,Ines de Santiago,Alexander Kukalev,Mario Nicodemi,Altuna Akalin,Meng Li,Mark A. Ungless,Ana Pombo +12 more
TL;DR: It is suggested that the tight interplay between RNAPII poising and Polycomb repression not only instructs promoter state transitions, but also may enable promoter plasticity in differentiated cells.