P
Philip M Nussenzweig
Researcher at Rockefeller University
Publications - 4
Citations - 836
Philip M Nussenzweig is an academic researcher from Rockefeller University. The author has contributed to research in topics: CRISPR & Population. The author has an hindex of 4, co-authored 4 publications receiving 592 citations. Previous affiliations of Philip M Nussenzweig include Kettering University.
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Journal ArticleDOI
Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials
David Bikard,Chad W. Euler,Wenyan Jiang,Philip M Nussenzweig,Gregory W. Goldberg,Xavier Duportet,Vincent A. Fischetti,Luciano A. Marraffini +7 more
TL;DR: It is shown that Cas9, reprogrammed to target virulence genes, kills virulent, but not avirulent, Staphylococcus aureus, and that CRISPR-Cas9 antimicrobials function in vivo to kill S. aUREus in a mouse skin colonization model.
Journal ArticleDOI
Molecular Mechanisms of CRISPR-Cas Immunity in Bacteria.
TL;DR: This work describes the many different molecular mechanisms of CRISPR targeting and how they are interconnected with the immunization phase through a third phase of theCRISPR-Cas immune response: primed spacer acquisition.
Journal ArticleDOI
Cas9 Cleavage of Viral Genomes Primes the Acquisition of New Immunological Memories
TL;DR: It is demonstrated that previously acquired spacers promote additional spacer acquisition from the vicinity of the target DNA site cleaved by Cas9, which anticipates the rise of escapers or related viruses that could escape targeting by the first spacer acquired.
Journal ArticleDOI
Viral Teamwork Pushes CRISPR to the Breaking Point.
TL;DR: It is shown that sequential infection gradually immunosuppresses the host to allow effective CRISPR inhibition.