V
Vincent A. Fischetti
Researcher at Rockefeller University
Publications - 350
Citations - 25941
Vincent A. Fischetti is an academic researcher from Rockefeller University. The author has contributed to research in topics: Lysin & Streptococcus pyogenes. The author has an hindex of 84, co-authored 341 publications receiving 24303 citations. Previous affiliations of Vincent A. Fischetti include New York University & University of California, Los Angeles.
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Book
Gram-positive pathogens
TL;DR: The final three chapters deal with principles of safe practice, including the role of clinical cytology in patient management, medicolegal considerations, and the contentious issue of the relative merits of fine needle aspiration and core biopsy.
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Streptococcal M protein: molecular design and biological behavior.
TL;DR: Many of the approaches described in the elucidation of the M-protein structure may be applied for characterizing similar molecules in other microbial systems.
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Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials
David Bikard,Chad W. Euler,Wenyan Jiang,Philip M Nussenzweig,Gregory W. Goldberg,Xavier Duportet,Vincent A. Fischetti,Luciano A. Marraffini +7 more
TL;DR: It is shown that Cas9, reprogrammed to target virulence genes, kills virulent, but not avirulent, Staphylococcus aureus, and that CRISPR-Cas9 antimicrobials function in vivo to kill S. aUREus in a mouse skin colonization model.
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Alternatives to antibiotics—a pipeline portfolio review
Lloyd George Czaplewski,Richard Bax,Martha R. J. Clokie,Michael J. Dawson,Heather Fairhead,Vincent A. Fischetti,Simon J. Foster,Brendan Gilmore,Robert E. W. Hancock,David R Harper,Ian R. Henderson,Kai Hilpert,Brian V. Jones,Brian V. Jones,Aras Kadioglu,David Knowles,Sigríður Ólafsdóttir,David J. Payne,Steve Projan,Sunil Shaunak,Jared Silverman,Christopher M. Thomas,Trevor J. Trust,Peter Warn,John H. Rex +24 more
TL;DR: This first wave of alternatives to antibiotics will probably best serve as adjunctive or preventive therapies, which suggests that conventional antibiotics are still needed.
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A major surface protein on group A streptococci is a glyceraldehyde-3-phosphate-dehydrogenase with multiple binding activity.
TL;DR: The multiple binding capacity of the SDH in conjunction with its GAPDH activity may play a role in the colonization, internalization, and the subsequent proliferation of group A streptococci.