P
Philip S. Perlman
Researcher at University of Texas Southwestern Medical Center
Publications - 115
Citations - 7931
Philip S. Perlman is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Intron & RNA splicing. The author has an hindex of 50, co-authored 115 publications receiving 7810 citations. Previous affiliations of Philip S. Perlman include Ohio State University & Howard Hughes Medical Institute.
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Journal ArticleDOI
A self-splicing RNA excises an intron lariat
Craig L. Peebles,Philip S. Perlman,K.L. Mecklenburg,M.L. Petrillo,J.H. Tabor,K.A. Jarrell,H.-L. Cheng +6 more
TL;DR: Results show that the class II intron products are similar to those of nuclear pre-mRNA splicing, particularly the spliced exons and broken form of the lariat.
Journal ArticleDOI
Group II intron mobility occurs by target DNA-primed reverse transcription
TL;DR: In vitro experiments show that homing of the yeast mtDNA group II intron aI2 occurs by reverse transcription at a double-strand break in the recipient DNA, raising the possibility that mobile group II introns were ancestors of nuclear non-long terminal repeat retrotransposons and telomerases.
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A group II intron RNA is a catalytic component of a DNA endonuclease involved in intron mobility
TL;DR: This work shows that the site-specific DNA endonuclease that makes the double-strand break is a ribonucleoprotein complex containing the al2-encoded reverse transcriptase protein and excised al2 RNA, and demonstrates a biologically relevant ribozyme reaction with a substrate other than RNA.
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Involvement of aminoacyl-tRNA synthetases and other proteins in group I and group II intron splicing
TL;DR: It is suggested that some of these protein-assisted splicing reactions evolved relatively recently, possibly reflecting the recent dispersal of the introns themselves.