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Craig L. Peebles
Researcher at University of Pittsburgh
Publications - 27
Citations - 3246
Craig L. Peebles is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: RNA splicing & Group II intron. The author has an hindex of 21, co-authored 27 publications receiving 3120 citations.
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Journal ArticleDOI
Mechanism of action of nalidixic acid: Purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme
TL;DR: It is postulate that the nalA gene product occurs in two molecular forms, as Pnal and as a gyrase component, and inhibition of this activity by nalidixic and oxolinic acids may account for the inhibition of DNA synthesis by these drugs.
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A self-splicing RNA excises an intron lariat
Craig L. Peebles,Philip S. Perlman,K.L. Mecklenburg,M.L. Petrillo,J.H. Tabor,K.A. Jarrell,H.-L. Cheng +6 more
TL;DR: Results show that the class II intron products are similar to those of nuclear pre-mRNA splicing, particularly the spliced exons and broken form of the lariat.
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Energy coupling in DNA gyrase and the mechanism of action of novobiocin
TL;DR: It is postulate that ATP and App[NH]p are allosteric effectors of a conformational change of gyrase that leads to one round of supercoiling and that cyclic conformational changes accompanying alteration in nucleotide affinity also seem to be a common feature of energy transduction in other diverse processes including muscle contraction, protein synthesis, and oxidative phosphorylation.
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Comparative genomic analysis of 60 Mycobacteriophage genomes: genome clustering, gene acquisition, and gene size.
Graham F. Hatfull,Deborah Jacobs-Sera,Jeffrey G. Lawrence,Welkin H. Pope,Daniel A. Russell,Ching-Chung Ko,Rebecca J. Weber,Manisha C. Patel,Katherine L. Germane,Robert H. Edgar,Natasha N. Hoyte,Charles A. Bowman,Anthony T. Tantoco,Elizabeth C. Paladin,Marlana S. Myers,Alexis L. Smith,Molly S. Grace,Thuy T. Pham,Matthew B. O'Brien,Amy M. Vogelsberger,Andrew J. Hryckowian,Jessica L. Wynalek,Helen Donis-Keller,Matt W. Bogel,Craig L. Peebles,Steven G. Cresawn,Roger W. Hendrix +26 more
TL;DR: Expansion of a collection of sequenced phage genomes to a total of 60-all infecting a common bacterial host-provides further insight into their diversity and evolution.
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Exploring the Mycobacteriophage Metaproteome: Phage Genomics as an Educational Platform
Graham F. Hatfull,Marisa L. Pedulla,Deborah Jacobs-Sera,Pauline M Cichon,Amy Foley,Michael E. Ford,Rebecca M Gonda,Jennifer M. Houtz,Andrew J. Hryckowian,Vanessa A Kelchner,Swathi Namburi,Kostandin V Pajcini,Mark G Popovich,Donald T Schleicher,Brian Simanek,Alexis L. Smith,G. Zdanowicz,Vanaja Kumar,Craig L. Peebles,William R. Jacobs,Jeffrey G. Lawrence,Roger W. Hendrix +21 more
TL;DR: The abundance and diversity of phages, the simplicity ofphage isolation, and the relatively small size of phage genomes support bacteriophage isolation and comparative genomic analysis as a highly suitable platform for discovery-based education.