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Craig L. Peebles

Researcher at University of Pittsburgh

Publications -  27
Citations -  3246

Craig L. Peebles is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: RNA splicing & Group II intron. The author has an hindex of 21, co-authored 27 publications receiving 3120 citations.

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Mechanism of action of nalidixic acid: Purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme

TL;DR: It is postulate that the nalA gene product occurs in two molecular forms, as Pnal and as a gyrase component, and inhibition of this activity by nalidixic and oxolinic acids may account for the inhibition of DNA synthesis by these drugs.
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A self-splicing RNA excises an intron lariat

TL;DR: Results show that the class II intron products are similar to those of nuclear pre-mRNA splicing, particularly the spliced exons and broken form of the lariat.
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Energy coupling in DNA gyrase and the mechanism of action of novobiocin

TL;DR: It is postulate that ATP and App[NH]p are allosteric effectors of a conformational change of gyrase that leads to one round of supercoiling and that cyclic conformational changes accompanying alteration in nucleotide affinity also seem to be a common feature of energy transduction in other diverse processes including muscle contraction, protein synthesis, and oxidative phosphorylation.