Philippe Jaeger

TL;DR: Zoledronic acid infusions given at intervals of up to one year produce effects on bone turnover and bone density as great as those achieved with daily oral dosing with bisphosphonates with proven efficacy against fractures, suggesting that an annual infusion of zoledronic Acid might be an effective treatment for postmenopausal osteoporosis.

TL;DR: Low-dose estradiol (E2) given for 50 days at the age of 3 6/12 yr resulted in normalization of serum gonadotropin levels, regression of ovarian size, and increase of whole body and lumbar spine bone mineral density, but E2 replacement needs to be adjusted throughout childhood and puberty.

TL;DR: It is suggested that aging affects body composition and fuel metabolism differently in each gender, leading to reduced fat oxidation and accumulation of upper-body fat with loss of striated muscle in men, and to an increased ratio ofupper- to lower- body fat and bone loss in women, the latter depending on fat mass.

TL;DR: A significant relationship exists between bone density and disc degeneration, bone density is a highly important factor in the performance of interbody stabilization, andDisc degeneration is of moderate importance in spinal motion.

TL;DR: Due to the important and sustained inhibition of bone resorption induced by AHPrBP, a single infusion of 60 mg of the bisphosphonate leads to a rapid decline in activity and a long-standing remission of moderate Paget's disease, without significant side effects.