P
Philippe Lechat
Researcher at Pierre-and-Marie-Curie University
Publications - 143
Citations - 11315
Philippe Lechat is an academic researcher from Pierre-and-Marie-Curie University. The author has contributed to research in topics: Heart failure & Bisoprolol. The author has an hindex of 45, co-authored 140 publications receiving 10734 citations. Previous affiliations of Philippe Lechat include French Institute of Health and Medical Research.
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Journal ArticleDOI
Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS)
Marcus Flather,Marcelo C. Shibata,Andrew J.S. Coats,Dirk J. van Veldhuisen,Aleksandr Parkhomenko,Joszef Borbola,Alain Cohen-Solal,Dan Dumitrascu,Roberto Ferrari,Philippe Lechat,Jordi Soler-Soler,Luigi Tavazzi,Lenka Špinarová,Toman J,Michael Böhm,Stefan D. Anker,Simon G. Thompson,Philip A. Poole-Wilson +17 more
TL;DR: Nebivolol, a beta-blocker with vasodilating properties, is an effective and well-tolerated treatment for heart failure in the elderly.
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Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects
Jean-Sébastien Hulot,Alessandra Bura,Eric Villard,Michel Azizi,Véronique Remones,Catherine Goyenvalle,Martine Aiach,Philippe Lechat,Pascale Gaussem +8 more
TL;DR: The CYP2C19*2 loss-of-function allele is associated with a marked decrease in platelet responsiveness to clopidogrel in young healthy male volunteers and may therefore be an important genetic contributor to clopsinogrel resistance in the clinical setting.
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Clinical Effects of β-Adrenergic Blockade in Chronic Heart Failure A Meta-Analysis of Double-Blind, Placebo-Controlled, Randomized Trials
TL;DR: It is indicated that there is persuasive evidence supporting a favorable effect of beta-blockade on ejection fraction and the combined risk of death and hospitalization for heart failure.
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Expert consensus document on beta-adrenergic receptor blockers.
Jose Lopez-Sendon,Karl Swedberg,John J.V. McMurray,Juan Tamargo,Aldo P. Maggioni,Henry J. Dargie,Michal Tendera,Finn Waagstein,Jan Kjekshus,Philippe Lechat,Christian Torp-Pedersen +10 more
TL;DR: It is of great importance that guidelines and recommendations are presented in formats that are easily interpreted and their implementation programmes must also be well conducted.
Journal ArticleDOI
Heart rate and cardiac rhythm relationships with bisoprolol benefit in chronic heart failure in CIBIS II Trial.
Philippe Lechat,Jean-Sébastien Hulot,Sylvie Escolano,Alain Mallet,Alain Leizorovicz,Marie Werhlen-Grandjean,Gilbert Pochmalicki,Henry J. Dargie +7 more
TL;DR: B HR and HRC are significantly related to prognosis in heart failure and bisoprolol-induced benefit over placebo for survival was observed to a similar extent at any level of both BHR and HRC.