P
Philippe Marianneau
Researcher at Pasteur Institute
Publications - 49
Citations - 2485
Philippe Marianneau is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Virus & Dengue virus. The author has an hindex of 24, co-authored 44 publications receiving 2283 citations. Previous affiliations of Philippe Marianneau include French Institute of Health and Medical Research & ANSES.
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Journal ArticleDOI
Liver histopathology and biological correlates in five cases of fatal dengue fever in Vietnamese children
Michel Huerre,Nguyen Trong Lan,Philippe Marianneau,Nguyen Bac Hue,Huot Khun,Nguyen Thanh Hung,Nguyen Thi Khen,Marie-Thérèse Drouet,Vu Thi Que Huong,Do Quang Ha,Y. Buisson,Vincent Deubel +11 more
TL;DR: It is suggested that the hepatocyte and Kupffer cells may be target cells supporting virus replication and that the councilman body is an apoptotic cell, as in the pathogenesis of yellow fever.
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Report of a fatal case of dengue infection with hepatitis: Demonstration of dengue antigens in hepatocytes and liver apoptosis
Anne Couvelard,Philippe Marianneau,Christophe Bedel,Marie-Thérèse Drouet,François Vachon,Dominique Hénin,Vincent Deubel +6 more
TL;DR: Findings suggest that hepatocytes are the major sites of DEN virus replication in the liver and that DEN virus induces apoptosis of hepatocytes in vivo.
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Nipah Virus: Vaccination and Passive Protection Studies in a Hamster Model
Vanessa Guillaume,Hugues Contamin,Philippe Loth,Marie-Claude Georges-Courbot,Anabelle Lefeuvre,Philippe Marianneau,K. B. Chua,Sai Kit Lam,Robin Buckland,Vincent Deubel,T. F. Wild +10 more
TL;DR: It is shown that both of the Nipah virus glycoproteins (G and F) when expressed as vaccinia virus recombinants induced an immune response in hamsters which protected against a lethal challenge by Nipahs virus.
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Dengue virus replication in human hepatoma cells activates NF-kappaB which in turn induces apoptotic cell death.
TL;DR: It is shown here that infection of the hepatoma cell line HepG2 with DEN type 1 virus induced cell death typical of apoptosis late in the virus cycle, and this may be a key element in the pathophysiology of hepatic failure associated with DHF-DSS.
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A golden hamster model for human acute Nipah virus infection
K. Thong Wong,Isabelle Grosjean,Christine Brisson,Barissa Blanquier,Michelle Fèvre-Montange,Arlette Bernard,Philippe Loth,Marie Claude Georges-Courbot,Michelle Chevallier,Hideo Akaoka,Philippe Marianneau,Sai Kit Lam,T. Fabian Wild,Vincent Deubel +13 more
TL;DR: A golden hamster (Mesocricetus auratus) model is proposed as a suitable model for further studies including pathogenesis studies, anti-viral drug testing, and vaccine development against acute Nipah infection.