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Philippe Menu
Researcher at University of Lausanne
Publications - 9
Citations - 6084
Philippe Menu is an academic researcher from University of Lausanne. The author has contributed to research in topics: Inflammasome & Internal medicine. The author has an hindex of 6, co-authored 6 publications receiving 5167 citations.
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Journal ArticleDOI
A role for mitochondria in NLRP3 inflammasome activation
TL;DR: It is shown that mitophagy/autophagy blockade leads to the accumulation of damaged, ROS-generating mitochondria, and this in turn activates the NLRP3 inflammasome, and may explain the frequent association of mitochondrial damage with inflammatory diseases.
Journal ArticleDOI
Erratum: A role for mitochondria in NLRP3 inflammasome activation
TL;DR: This corrects the article to show that the H2O2/H2O/O2 balance is determined by a combination of H2A and O2 values, not by a single substance called “h2O”.
Journal ArticleDOI
Malarial hemozoin is a Nalp3 inflammasome activating danger signal.
Catherine Dostert,Greta Guarda,Jackeline F. Romero,Philippe Menu,Olaf Gross,Aubry Tardivel,Mario-Luca Suvà,Jean-Christophe Stehle,Manfred Kopf,Ivan Stamenkovic,Giampietro Corradin,Jürg Tschopp +11 more
TL;DR: It is found that hemozoin acts as a proinflammatory danger signal that activates the Nalp3 inflammasome, causing the release of IL-1β in mice infected with Plasmodium berghei sporozoites.
Journal ArticleDOI
Differential Expression of NLRP3 among Hematopoietic Cells
Greta Guarda,Manuel Zenger,Manuel Zenger,Amir S. Yazdi,Kate Schroder,Kate Schroder,Isabel Ferrero,Philippe Menu,Aubry Tardivel,Chantal Mattmann,Jiirg Tschopp +10 more
TL;DR: This study generated a knock-in mouse in which the Nlrp3 coding sequence was substituted for the GFP (enhanced GFP [egfp]) gene, and it is shown that eGFP expression indeed mirrors that of NLRP3.
Journal ArticleDOI
ER stress activates the NLRP3 inflammasome via an UPR-independent pathway
Philippe Menu,Annick Mayor,Rongbin Zhou,Rongbin Zhou,Aubry Tardivel,Hidenori Ichijo,Kazutoshi Mori,J. Tschopp +7 more
TL;DR: It is proposed that the NLRP3 inflammasome senses and responds to ER stress downstream of a previously uncharacterized ER stress response signaling pathway distinct from the UPR, thus providing mechanistic insight to the link between ER stress and chronic inflammatory diseases.