C
Catherine Dostert
Researcher at University of Lausanne
Publications - 22
Citations - 8031
Catherine Dostert is an academic researcher from University of Lausanne. The author has contributed to research in topics: Inflammasome & NALP3. The author has an hindex of 16, co-authored 17 publications receiving 7307 citations. Previous affiliations of Catherine Dostert include École normale supérieure de Lyon & University of Luxembourg.
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Journal ArticleDOI
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica.
Catherine Dostert,Virginie Pétrilli,Robin van Bruggen,Chad Steele,Brooke T. Mossman,Jürg Tschopp +5 more
TL;DR: It is shown that asbestos and silica are sensed by the Nalp3 inflammasome, whose subsequent activation leads to interleukin-1β secretion, and support its role as a major proinflammatory “danger” receptor in particulate matter–related pulmonary diseases.
Journal ArticleDOI
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration.
Virginie Pétrilli,Papin S,Catherine Dostert,Annick Mayor,Fabio Martinon,Fabio Martinon,J. Tschopp +6 more
TL;DR: Evidence is provided that activation of NALP3, but not of the IPAF inflammasome, is blocked by inhibiting K+ efflux from cells, suggesting that low intracellular K+ may be the least common trigger of NalP-inflammasomes activation.
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Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence.
Olaf Gross,Olaf Gross,Hendrik Poeck,Michael Bscheider,Catherine Dostert,Nicole Hannesschläger,Stefan Endres,Gunther Hartmann,Aubry Tardivel,Edina Schweighoffer,Victor L. J. Tybulewicz,Attila Mócsai,Jürg Tschopp,Jürgen Ruland +13 more
TL;DR: The results demonstrate the molecular basis for IL-1β production after fungal infection and identify a crucial function for the Nlrp3 inflammasome in mammalian host defence in vivo.
Journal ArticleDOI
The inflammasome: a danger sensing complex triggering innate immunity.
TL;DR: The important role of the NalP3 inflammasome is emphasized by the identification of mutations in the NALP3 gene that are associated with a susceptibility to inflammatory disorders.
Journal ArticleDOI
The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila.
Catherine Dostert,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Phil Irving,Laurent Troxler,Delphine Galiana-Arnoux,Charles Hetru,Jules A. Hoffmann,Jean-Luc Imler +8 more
TL;DR: Results indicate that in addition to Toll and Imd, a third, evolutionary conserved innate immunity pathway functions in drosophila and counters viral infection.