Jean-Christophe Stehle

TL;DR: It is shown that targeted pharmacologic disruption of EZH2 by the S-adenosylhomocysteine hydrolase inhibitor 3-deazaneplanocin A (DZNep), or its specific downregulation by short hairpin RNA (shRNA), strongly impairs GBM cancer stem cell (CSC) self-renewal in vitro and tumor-initiating capacity in vivo.

TL;DR: It is found that hemozoin acts as a proinflammatory danger signal that activates the Nalp3 inflammasome, causing the release of IL-1β in mice infected with Plasmodium berghei sporozoites.

TL;DR: This article showed that expression of EWS-FLI-1 fusion protein in human mesenchymal stem cells (hMSC) is not only stably maintained without inhibiting proliferation but also induces a gene expression profile bearing striking similarity to that of Ewing's sarcoma, including genes that are among the highest ESFT discriminators.

TL;DR: These observations provide the first identification of ESFT cancer stem cells and demonstration of their MSC properties, a critical step towards a better biological understanding and rational therapeutic targeting of these tumors.

TL;DR: Insight is provided for the first time into the mechanisms whereby a single oncogene can reprogram primary cells to display a CSC phenotype and the common target gene, SOX2, in addition to miRNA145 itself, is identified as key players in ESFT cell differentiation and tumorigenicity.