G
Giampietro Corradin
Researcher at University of Lausanne
Publications - 259
Citations - 12160
Giampietro Corradin is an academic researcher from University of Lausanne. The author has contributed to research in topics: Antigen & Epitope. The author has an hindex of 55, co-authored 256 publications receiving 11771 citations. Previous affiliations of Giampietro Corradin include University Hospital of Lausanne & ISREC.
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Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells
Paola Panina-Bordignon,Agnes Tan,Annemarie Termijtelen,Stefan Demotz,Giampietro Corradin,Antonio Lanzavecchia +5 more
TL;DR: The analysis of specific clones indicates that both p2 and p30 are very promiscuous in their capacity to bind to class II.
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Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria
Pedro Romero,Janet L. Maryanski,Giampietro Corradin,Ruth S. Nussenzweig,Victor Nussenzweig,Fidel Zavala +5 more
TL;DR: In this article, an epitope contained within amino acids 249-260 of the Plasmodium berghei circumsporozoite protein was identified by H-2Kd-restricted cytotoxic T cells.
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Malarial hemozoin is a Nalp3 inflammasome activating danger signal.
Catherine Dostert,Greta Guarda,Jackeline F. Romero,Philippe Menu,Olaf Gross,Aubry Tardivel,Mario-Luca Suvà,Jean-Christophe Stehle,Manfred Kopf,Ivan Stamenkovic,Giampietro Corradin,Jürg Tschopp +11 more
TL;DR: It is found that hemozoin acts as a proinflammatory danger signal that activates the Nalp3 inflammasome, causing the release of IL-1β in mice infected with Plasmodium berghei sporozoites.
Journal Article
Lymphocyte Specificity to Protein Antigens: I. Characterization of the Antigen-Induced in Vitro T Cell-Dependent Proliferative Response with Lymph Node Cells from Primed Mice
TL;DR: An in vitro assay which measures antigen-induced proliferation of primed murine lymph node cells is described, finding that LN cells from nu/nu mice injected with antigen do not demonstrate antigen- induced proliferation in contrast to the response observed in euthymic littermate controls.
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The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host
Alida Coppi,Ramya Natarajan,Gabriele Pradel,Brandy L. Bennett,Eric R. James,Mario Roggero,Giampietro Corradin,Cathrine Persson,Rita Tewari,Photini Sinnis +9 more
TL;DR: Conformational changes influence functional properties of circumsporozoite protein expressed on the surface of Plasmodium sporozoites.