Philippe Saas

TL;DR: It is reported that the nonclassic human leukocyte antigen (HLA) class I molecule HLA‐G is responsible for the immunomodulatory properties of MSCs and it is demonstrated that in addition to their action on the adaptive immune system, M SCs, through HLA•G5, affect innate immunity by inhibiting both NK cell‐mediated cytolysis and interferon‐γ secretion.

TL;DR: The findings suggest that FasL-induced apoptosis by astrocytoma cells may play a significant role in both immunosuppression and the regulation of tumor growth within the central nervous system.

TL;DR: The potential interactions between tumor cells and the host immune response are thus more complex than previously thought; their elucidation will benefit the rational design of cancer immunotherapy strategies.

TL;DR: Overall, the administration of low numbers of HS-tk-expressing T cells early following an HLA-identical BMT is associated with no acute toxicity, persistent circulation of the GMCs, and GCV-sensitive GVHD, and open the way to the infusion of higher numbers of gene-modified donor T cells to enhance post-BMT immune competence while preserving GCv-sensitive alloreactivity.

TL;DR: In this paper, the authors show that treatment of normal mice with intact antibody to CD3 increases systemic transforming growth factor-beta (TGF-beta) produced by phagocytes exposed to apoptotic T cells, which suggests that apoptosis is linked to active suppression in immune tolerance.