C
Christophe Ferrand
Researcher at French Institute of Health and Medical Research
Publications - 148
Citations - 4653
Christophe Ferrand is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Transplantation & Cytotoxic T cell. The author has an hindex of 34, co-authored 142 publications receiving 4114 citations. Previous affiliations of Christophe Ferrand include Imperial College London & Netherlands Cancer Institute.
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Administration of herpes simplex–thymidine kinase–expressing donor T cells with a T-cell–depleted allogeneic marrow graft
Pierre Tiberghien,Christophe Ferrand,Bruno Lioure,Noel Milpied,Régis Angonin,Eric Deconinck,Jean-Marie Certoux,Eric Robinet,Philippe Saas,Bruno Petracca,Chris Juttner,Craig W. Reynolds,Dan L. Longo,Patrick Hervé,Jean-Yves Cahn +14 more
TL;DR: Overall, the administration of low numbers of HS-tk-expressing T cells early following an HLA-identical BMT is associated with no acute toxicity, persistent circulation of the GMCs, and GCV-sensitive GVHD, and open the way to the infusion of higher numbers of gene-modified donor T cells to enhance post-BMT immune competence while preserving GCv-sensitive alloreactivity.
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Evidence of premature immune aging in patients thymectomized during early childhood
Delphine Sauce,Martin Larsen,Solène Fastenackels,Anne Duperrier,Michael Keller,Beatrix Grubeck-Loebenstein,Christophe Ferrand,Patrice Debré,Daniel Sidi,Victor Appay +9 more
TL;DR: It is shown that young adults thymectomized during early childhood exhibit an altered T cell compartment and this condition was directly related to CMV infection and the induction of strong CMV-specific T cell responses, which may exhaust the naive T cell pool in the absence of adequate T cell renewal from the thymus.
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High frequency of GATA2 mutations in patients with mild chronic neutropenia evolving to MonoMac syndrome, myelodysplasia, and acute myeloid leukemia.
Marlène Pasquet,Christine Bellanné-Chantelot,Suzanne Tavitian,Naïs Prade,Blandine Beaupain,Olivier LaRochelle,Arnaud Petit,Pierre Rohrlich,Christophe Ferrand,Eric Van Den Neste,Hélène Poirel,Thierry Lamy,Marie Ouachée-Chardin,Véronique Mansat-De Mas,Véronique Mansat-De Mas,Jill Corre,Jill Corre,Christian Recher,Christian Recher,Geneviève Plat,Françoise Bachelerie,Jean Donadieu,Eric Delabesse,Eric Delabesse +23 more
TL;DR: The importance of screening GATA2 in chronic neutropenia associated with monocytopenia because of the frequent hematopoietic transformation, variable clinical expression at onset, and the need for aggressive therapy in patients with poor clinical outcome is revealed.
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Relevance of Toll-like receptor-4 polymorphisms in renal transplantation.
Didier Ducloux,Marina Deschamps,Maria Yannaraki,Christophe Ferrand,Jamal Bamoulid,Philippe Saas,Amir Kazory,Jean-Marc Chalopin,Pierre Tiberghien +8 more
TL;DR: RTR with TLR4 polymorphism present a lower risk of post-transplant atherosclerotic events and acute allograft rejection, but experience severe infectious episodes more frequently.
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Extended diagnostic criteria for plasmacytoid dendritic cell leukaemia.
Francine Garnache-Ottou,Jean Feuillard,Christophe Ferrand,Sabeha Biichle,Franck Trimoreau,Estelle Seilles,Véronique Salaun,Richard Garand,Pascale Lepelley,Marc Maynadié,Emilienne Kuhlein,Eric Deconinck,Sylvie Daliphard,Laurence Chaperot,Lucille Beseggio,Vincent Foisseaud,Elizabeth Macintyre,Marie-Christine Béné,Philippe Saas,Marie-Christine Jacob +19 more
TL;DR: This study validated pDCL‐specific markers for diagnosis by flow‐cytometry or quantitative reverse transcription polymerase chain reaction on bone marrow samples and proposed a diagnosis strategy, scoring first the CD4+ CD56+/− MPOneg cCD3neg cCD79aneg CD11cneg profile and then the CD123high,BDCA‐2 and BDCA‐4 expression.