Pier Luigi Acutis

TL;DR: Evidence of a second cattle TSE is provided, pathologically characterized by the presence of PrP-immunopositive amyloid plaques, as opposed to the lack of amyloids deposition in typical BSE cases, and by a different pattern of regional distribution and topology of brain PrP(Sc) accumulation.

TL;DR: H-type BSE isolates exhibited differences in the binding of antibodies specific for N- and more C-terminal PrP regions and principally contained two aglycosylated PrPres moieties which are indicative of the existence of two PrPres populations or intermediate cleavage sites and might assist with the recognition of other variants.

TL;DR: It is shown that the agents responsible for BSE and BASE possess different biological properties upon transmission to transgenic mice expressing bovine PrP and inbred lines of nontransgenic mice, which results in a neuropathological and molecular disease phenotype indistinguishable from that of BSE-infected mice.

TL;DR: Investigating the infectivity and human phenotype of BASE strains by inoculating transgenic mice with human prion protein with brain homogenates from two BASE strain-infected cattle suggests that in humans, the BASE strain is a more virulent BSE strain and likely lymphotropic.

TL;DR: This review presents the current knowledge of the epidemiology of caprine scrapie within the major European goat populations, and compiles the current data on genetic variability of PRNP.