P
Pierre J. Dilda
Researcher at University of Paris
Publications - 67
Citations - 1441
Pierre J. Dilda is an academic researcher from University of Paris. The author has contributed to research in topics: Mitochondrion & Apoptosis. The author has an hindex of 19, co-authored 59 publications receiving 1268 citations. Previous affiliations of Pierre J. Dilda include University of New South Wales & Australian National University.
Papers
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Journal ArticleDOI
Arsenical-based cancer drugs.
Pierre J. Dilda,Philip J. Hogg +1 more
TL;DR: A new class or organoarsenicals are being trialed for the treatment of hematological malignancies and solid tumors and Mechanisms of action and selectivity and acute and chronic toxicities are discussed along with the prospects of this class of molecule.
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A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells.
Anthony S. Don,Oliver Kisker,Pierre J. Dilda,Neil Donoghue,Xueyun Zhao,Stephanie Decollogne,Belinda Creighton,Evelyn Flynn,Judah Folkman,Philip J. Hogg,Philip J. Hogg +10 more
TL;DR: GSAO inhibited angiogenesis in the chick chorioallantoic membrane and in solid tumors in mice and inhibited tumor growth in mice with no apparent toxicity at efficacious doses.
Journal ArticleDOI
Glutathione S-conjugates as prodrugs to target drug-resistant tumors.
Emma Ramsay,Pierre J. Dilda +1 more
TL;DR: This strategy, explored over the last two decades, has recently been successful using GST-activated nitrogen mustard and γGT-activated arsenic-based prodrugs confirming the potential of GSH-conjugates as anticancer drugs.
Journal ArticleDOI
Sensitization of Glioblastoma Cells to Irradiation by Modulating the Glucose Metabolism
TL;DR: The proof of concept that dichloroacetate can effectively sensitize glioblastoma cells to radiotherapy by modulating the metabolic state of tumor cells is provided.
Journal ArticleDOI
Noninvasive imaging of cell death using an Hsp90 ligand.
Danielle Park,Anthony S. Don,Tania Massamiri,Amol Karwa,Beth Warner,Jan MacDonald,Christine L. Hemenway,Arati D. Naik,Kah Tiong Kuan,Pierre J. Dilda,Jason W. H. Wong,Kevin Camphausen,Lori K. Chinen,Mary Dyszlewski,Philip J. Hogg +14 more
TL;DR: A small organoarsenical compound, 4-(N-(S-glutathionylacetylamino)phenylarsonous acid, that rapidly accumulates in the cytosol of dying cells coincident with loss of plasma membrane integrity, should enable the imaging of cell death in most experimental settings.