P
Pierre-Louis Leger
Researcher at University of Paris
Publications - 52
Citations - 936
Pierre-Louis Leger is an academic researcher from University of Paris. The author has contributed to research in topics: Medicine & Extracorporeal membrane oxygenation. The author has an hindex of 13, co-authored 40 publications receiving 591 citations. Previous affiliations of Pierre-Louis Leger include Paris Universitas & French Institute of Health and Medical Research.
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Journal ArticleDOI
Association of Intravenous Immunoglobulins Plus Methylprednisolone vs Immunoglobulins Alone With Course of Fever in Multisystem Inflammatory Syndrome in Children.
Naim Ouldali,Julie Toubiana,Denise Antona,Etienne Javouhey,Fouad Madhi,Mathie Lorrot,Pierre-Louis Leger,Caroline Galeotti,Caroline Claude,Arnaud Wiedemann,Noémie Lachaume,Caroline Ovaert,Morgane Dumortier,Jean-Emmanuel Kahn,Alexis Mandelcwajg,Lucas Percheron,Blandine Biot,Jeanne Bordet,Marie-Laure Girardin,David D. Yang,Marion Grimaud,Mehdi Oualha,Slimane Allali,Fanny Bajolle,Constance Beyler,Ulrich Meinzer,Ulrich Meinzer,Michael Levy,Ana-Maria Paulet,Corinne Levy,Robert Cohen,Alexandre Belot,François Angoulvant +32 more
TL;DR: In this article, the authors compared intravenous immunoglobulins (IVIG) plus methylprednisolone vs IVIG alone as initial therapy in multisystem inflammatory syndrome in children (MIS-C).
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Invasive Pneumococcal Disease in Children Can Reveal a Primary Immunodeficiency
Jean Gaschignard,Corinne Levy,Maya Chrabieh,Bertrand Boisson,Cécile Bost-Bru,Stéphane Dauger,François Dubos,Philippe Durand,Joël Gaudelus,Dominique Gendrel,Christèle Gras-Le Guen,Emmanuel Grimprel,Gaël Guyon,Catherine Jeudy,Eric Jeziorski,Francis Leclerc,Pierre-Louis Leger,Fabrice Lesage,Mathie Lorrot,Isabelle Pellier,Didier Pinquier,Loïc de Pontual,P. Sachs,Caroline Thomas,Pierre Tissières,Frédéric V. Valla,Philippe Desprez,Véronique Frémeaux-Bacchi,Emmanuelle Varon,Xavier Bossuyt,Robert M. Cohen,Laurent Abel,Jean-Laurent Casanova,Anne Puel,Capucine Picard +34 more
TL;DR: Children with IPD should undergo immunological investigations, particularly those aged >2 years, as PIDs may be discovered in up to 26% of cases, much higher in children aged>2 years than in younger children.
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Inhaled Nitric Oxide Reduces Brain Damage by Collateral Recruitment in a Neonatal Stroke Model
Christiane Charriaut-Marlangue,Philippe Bonnin,Abdallah Gharib,Pierre-Louis Leger,Sonia Villapol,Marc Pocard,Pierre Gressens,Sylvain Renolleau,Olivier Baud +8 more
TL;DR: The findings strongly indicate that, with the appropriate timing, 20 ppm iNO can be transported into the P7 rat brain and mediated blood flow redistribution during ischemia leading to reduced infarct volume and cell injury.
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Endothelial S1P 1 Signaling Counteracts Infarct Expansion in Ischemic Stroke
Anja Nitzsche,Marine Poittevin,Ammar Benarab,Philippe Bonnin,Giuseppe Faraco,Hiroki Uchida,Julie Favre,Lidia Garcia-Bonilla,Manuela Cl Garcia,Pierre-Louis Leger,Patrice Therond,Thomas Mathivet,Gwennhael Autret,Véronique Baudrie,Ludovic Couty,Mari Kono,Aline Chevallier,Hira Niazi,Pierre-Louis Tharaux,Jerold Chun,Susan R. Schwab,Anne Eichmann,Bertrand Tavitian,Richard L. Proia,Christiane Charriaut-Marlangue,Teresa Sanchez,Nathalie Kubis,Daniel Henrion,Costantino Iadecola,Timothy Hla,Eric Camerer +30 more
TL;DR: Genetic evidence is provided to support a pivotal role for the endothelium in maintaining perfusion and microvascular patency in the ischemic penumbra that is coordinated by S1P signaling and can be harnessed for neuroprotection with BBB-penetrating S 1P1 agonists.
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Sildenafil Mediates Blood-Flow Redistribution and Neuroprotection After Neonatal Hypoxia-Ischemia
Christiane Charriaut-Marlangue,Thao Nguyen,Philippe Bonnin,An Phan Duy,Pierre-Louis Leger,Zsolt Csaba,Julien Pansiot,Thomas Bourgeois,Sylvain Renolleau,Olivier Baud +9 more
TL;DR: Findings strongly indicate that sildenafil citrate treatment, associated with a significant increase in cerebral blood flow, reduces HI damage and improves motor locomotion in neonatal rats.