P
Pierre Val
Researcher at University of Auvergne
Publications - 80
Citations - 2429
Pierre Val is an academic researcher from University of Auvergne. The author has contributed to research in topics: Adrenal cortex & Wnt signaling pathway. The author has an hindex of 26, co-authored 58 publications receiving 2133 citations. Previous affiliations of Pierre Val include French Institute of Health and Medical Research & Blaise Pascal University.
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Journal ArticleDOI
SF-1 a key player in the development and differentiation of steroidogenic tissues.
TL;DR: This extensive review takes into account recent data obtained fromSF-1 haploinsufficient mice, pituitary-specific knock-outs and from transgenic mice experiments carried out with SF-1 target gene promoters and summarizes the pros and cons regarding the presumed role of SF- 1 in cAMP signalling.
Journal ArticleDOI
Constitutive β-catenin activation induces adrenal hyperplasia and promotes adrenal cancer development
A. Berthon,Isabelle Sahut-Barnola,Isabelle Sahut-Barnola,Sarah Lambert-Langlais,Sarah Lambert-Langlais,Cyrille de Joussineau,Cyrille de Joussineau,Christelle Damon-Soubeyrand,Christelle Damon-Soubeyrand,Estelle Louiset,Mark M. Taketo,Frédérique Tissier,Frédérique Tissier,Jérôme Bertherat,Jérôme Bertherat,Anne Marie Lefrançois-Martinez,Anne Marie Lefrançois-Martinez,Antoine Martinez,Antoine Martinez,Pierre Val,Pierre Val +20 more
TL;DR: In this article, constitutive activation of beta-catenin in the adrenal cortex of transgenic mice resulted in progressive steroidogenic and undifferentiated spindle-shaped cells hyperplasia as well as dysplasia of the cortex and medulla.
Journal ArticleDOI
WNT/β-catenin Signalling is Activated in Aldosterone Producing Adenomas and Controls Aldosterone Production
A. Berthon,Coralie Drelon,Coralie Drelon,Coralie Drelon,Bruno Ragazzon,Bruno Ragazzon,Sheerazed Boulkroun,Sheerazed Boulkroun,Frédérique Tissier,Laurence Amar,Laurence Amar,Benoit Samson-Couterie,Benoit Samson-Couterie,Maria-Christina Zennaro,Maria-Christina Zennaro,Pierre-François Plouin,Pierre-François Plouin,Seham Skah,Michelina Plateroti,Hervé Lefebvre,Isabelle Sahut-Barnola,Isabelle Sahut-Barnola,Isabelle Sahut-Barnola,M. Batisse-Lignier,Guillaume Assié,Guillaume Assié,Anne-Marie Lefrançois-Martinez,Anne-Marie Lefrançois-Martinez,Anne-Marie Lefrançois-Martinez,Jérôme Bertherat,Jérôme Bertherat,Antoine Martinez,Antoine Martinez,Antoine Martinez,Pierre Val,Pierre Val,Pierre Val +36 more
TL;DR: Data show that aberrant WNT/β-catenin activation is associated with APA development and suggest that WNT pathway may be a good therapeutic target in PA.
Journal ArticleDOI
Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage
TL;DR: A regulatory mechanism in which Cited2 acts as a Wt1 co-factor to increase, at a critical time in embryogenesis, the levels of the essential transcription factor Sf-1 in the AGP above the threshold required to determine adrenal development is revealed.
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Wnt/β-catenin signalling in adrenal physiology and tumour development.
TL;DR: This review will summarise all of the recent findings and will focus on some of the mechanisms that may lead to aberrant accumulation of β-catenin in adrenocortical tumours.